Carbonic anhydrase inhibitors targeting metabolism and tumor microenvironment
The tumor microenvironment is crucial for the growth of cancer cells, triggering particular
biochemical and physiological changes, which frequently influence the outcome of …
biochemical and physiological changes, which frequently influence the outcome of …
Recent advances in the medicinal chemistry of carbonic anhydrase inhibitors
Abstract Carbonic anhydrase (CA, EC 4.2. 1.1) is an enzyme and a very omnipresent zinc
metalloenzyme which catalyzed the reversible hydration and dehydration of carbon dioxide …
metalloenzyme which catalyzed the reversible hydration and dehydration of carbon dioxide …
Recent advancements in the development of bioactive pyrazoline derivatives
Pyrazolines remain privileged heterocycles in drug discovery. 2-Pyrazoline scaffold has
been proven as a ubiquitous motif which is present in a number of pharmacologically …
been proven as a ubiquitous motif which is present in a number of pharmacologically …
[HTML][HTML] A comprehensive review on pyrazoline based heterocyclic hybrids as potent anticancer agents
Cancer is one of the leading causes of death globally, around 10 million deaths are reported
every year due to cancer. Some clinically approved anticancer drugs play a riveting role in …
every year due to cancer. Some clinically approved anticancer drugs play a riveting role in …
Synthesis, structure elucidation, and in vitro pharmacological evaluation of novel polyfluoro substituted pyrazoline type sulfonamides as multi-target agents for …
Abstract A novel series of 4-(3-(difluorophenyl)-5-(dimethoxyphenyl)-4, 5-dihydropyrazol-1-
yl) benzenesulfonamides 1–8 were designed since sulfonamide and pyrazoline …
yl) benzenesulfonamides 1–8 were designed since sulfonamide and pyrazoline …
Novel adamantane-pyrazole and hydrazone hybridized: Design, synthesis, cytotoxic evaluation, SAR study and molecular docking simulation as carbonic anhydrase …
MMS Wassel, A Ragab, GAME Ali, ABM Mehany… - Journal of Molecular …, 2021 - Elsevier
A series of pyrazole derivatives 4, 5, 6, 12, 13, 14 as well as hydrazone derivatives 7, 10, 11
were synthesized starting from adamantane-1-carbohydrazide as the bioactive core. All …
were synthesized starting from adamantane-1-carbohydrazide as the bioactive core. All …
Investigation on hydrazonobenzenesulfonamides as human carbonic anhydrase I, II, IX and XII inhibitors
A small series of hydrazonobenzenesulfonamides was designed, synthesized and studied
for their human carbonic anhydrase (hCA) inhibitory activity. The synthesized compounds …
for their human carbonic anhydrase (hCA) inhibitory activity. The synthesized compounds …
Enaminone-based carboxylic acids as novel non-classical carbonic anhydrases inhibitors: design, synthesis and in vitro biological assessment
In searching for new molecular drug targets, Carbonic Anhydrases (CAs) have emerged as
valuable targets in diverse diseases. CAs play critical functions in maintaining pH and CO2 …
valuable targets in diverse diseases. CAs play critical functions in maintaining pH and CO2 …
Design and synthesis of novel pyrazoline derivatives for their spectroscopic, single crystal X-ray and biological studies
Abstract N-Acyl-2-pyrazolines have been synthesized via cyclization of chalcones with
hydrazine hydrate in the presence of aliphatic acids. These pyrazolines (2a–c) were …
hydrazine hydrate in the presence of aliphatic acids. These pyrazolines (2a–c) were …
[PDF][PDF] Response to perspectives on the classical enzyme carbonic anhydrase and the search for inhibitors
In a recent paper by Jonsson and Liljas (1), some inhibition data from the supporting
information of several papers from the Supuran group were considered where carbonic …
information of several papers from the Supuran group were considered where carbonic …