Posttranslational modifications (PTMs) of proteins, the major mechanism of protein function
regulation, play important roles in regulating a variety of cellular physiological and …

Transcription factors (TFs) are proteins that interact with specific DNA sequences to regulate
gene expression and play crucial roles in all kinds of biological processes. To keep up with …

In 2008, we published the first set of guidelines for standardizing research in autophagy.
Since then, this topic has received increasing attention, and many scientists have entered …

Background Autophagy refers to the conserved cellular catabolic process relevant to
lysosome activity and plays a vital role in maintaining the dynamic equilibrium of intracellular …

Autophagy is a highly dynamic and multi-step process, regulated by many functional protein
units. Here, we have built up a comprehensive and up-to-date annotated gene list for the …

Autophagy is a major contributor to anti-cancer therapy resistance. Many efforts have been
made to understand and overcome autophagy-mediated therapy resistance, but these …

Autophagy can selectively target protein aggregates, pathogens, and dysfunctional
organelles for the lysosomal degradation. Aberrant regulation of autophagy promotes …

Dysfunction of macroautophagy/autophagy has been postulated as a major cellular
toxicological response to nanomaterials. It has been reported that excessive autophagy …

How autophagy initiation is regulated and what the functional significance of this regulation
is are unknown. Here, we characterized the role of yeast Vac8 in autophagy initiation …

Abstract The BIG Data Center at Beijing Institute of Genomics (BIG) of the Chinese Academy
of Sciences provides a suite of database resources in support of worldwide research …