Glutamatergic system components as potential biomarkers and therapeutic targets in cancer in non-neural organs

AC García-Gaytán, A Hernández-Abrego… - Frontiers in …, 2022 - frontiersin.org
Glutamate is one of the most abundant amino acids in the blood. Besides its role as a
neurotransmitter in the brain, it is a key substrate in several metabolic pathways and a …

Role of Glutathione in Parkinson's Disease Pathophysiology and Therapeutic Potential of Polyphenols

C Niu, M Dong, Y Niu - Phytotherapy Research, 2024 - Wiley Online Library
Oxidative stress is recognized to have a central role in the initiation and progression of
Parkinson's disease (PD). Within the brain, neurons are particularly sensitive to oxidation …

[HTML][HTML] Compartmentalized role of xCT in supporting pancreatic tumor growth, inflammation and mood disturbance in mice

O Lara, P Janssen, M Mambretti, L De Pauw… - Brain, Behavior, and …, 2024 - Elsevier
Abstract xCT (Slc7a11), the specific subunit of the cystine/glutamate antiporter system x c-, is
present in the brain and on immune cells, where it is known to modulate behavior and …

Implication of system xc in neuroinflammation during the onset and maintenance of neuropathic pain

P Beckers, I Belo Do Nascimento, M Charlier… - Journal of …, 2024 - Springer
Background Despite the high prevalence of neuropathic pain, treating this neurological
disease remains challenging, given the limited efficacy and numerous side effects …

Isolation and monoculture of functional primary astrocytes from the adult mouse spinal cord

IL Peterson, AD Thompson, NE Scholpa… - Frontiers in …, 2024 - frontiersin.org
Astrocytes are a widely heterogenic cell population that play major roles in central nervous
system (CNS) homeostasis and neurotransmission, as well as in various neuropathologies …

Structural investigation of human cystine/glutamate antiporter system xc (Sxc ) using homology modeling and molecular dynamics

TD Hang, HM Hung, P Beckers, N Desmet… - Frontiers in Molecular …, 2022 - frontiersin.org
The cystine/glutamate antiporter system xc−(Sxc−) belongs to the SLC7 family of plasma
membrane transporters. It exports intracellular glutamate along the latter's concentration …

Hierro: desde la homeostasis a la muerte por ferroptosis

AJ Lazarowski, AA Vitale, JA Auzmendi… - Acta bioquímica …, 2022 - SciELO Argentina
Hierro: desde la homeostasis a la muerte por ferroptosis Page 1 Acta Bioquímica Clínica
Latinoamericana Incorporada al Chemical Abstract Service. Código bibliográfico: ABCLDL …