Introduction: Amorphous solid dispersions are considered as one of the most powerful
strategies to formulate poorly soluble drugs. They are made up of an active pharmaceutical …

Poor solubility and bioavailability of an existing or newly synthesized drug always pose
challenge in the development of efficient pharmaceutical formulation. Numerous …

Introduction: Poor aqueous solubility of active pharmaceutical ingredients (APIs) is one of
the main challenges in the development of new small molecular drugs. Additionally, the …

Objectives Hot melt extrusion (HME) as a technique for producing amorphous solid
dispersion (ASD) has been widely used in pharmaceutical research. The biggest challenge …

Currently, most of the approved protein and peptide-based medicines are delivered via
conventional parenteral injection (intramuscular, subcutaneous or intravenous). A frequent …

Spray drying is widely used in the manufacturing of amorphous solid dispersion (ASD)
systems due to its fast drying rate, enabling kinetic trapping of the drug in amorphous form …

The purpose of this study was to investigate the feasibility of using a fluorescence-based
technique to evaluate drug–polymer miscibility and to probe the correlation between …

The development of stable solid dispersion formulations that maintain desired improvement
of drug dissolution rate during the entire shelf life requires the analysis of drug-polymer …

Understanding the long-term stability of amorphous solid dispersions (ASDs) is important for
their successful approval for market. ASD stability does not only depend on the interplay …

The understanding of amorphous solid dispersions has grown significantly in the past
decade. This is evident from the number of approved commercial amorphous solid …