Spray-drying technology
DA Miller, D Ellenberger, T Porfirio, M Gil - Formulating poorly water …, 2022 - Springer
This chapter provides an in-depth review of spray-drying technology and its application to
the formulation of poorly water-soluble drugs. In the early part of the chapter, the …
the formulation of poorly water-soluble drugs. In the early part of the chapter, the …
Multicomponent solid dispersion a new generation of solid dispersion produced by spray-drying
LM De Mohac, B Raimi-Abraham, R Caruana… - Journal of Drug Delivery …, 2020 - Elsevier
The term “multicomponent solid dispersion” is widely used in recent literature to describe
solid formulations consisting of a special excipient's mixture and active molecules finely …
solid formulations consisting of a special excipient's mixture and active molecules finely …
New strategies for improving the development and performance of amorphous solid dispersions
The understanding of amorphous solid dispersions has grown significantly in the past
decade. This is evident from the number of approved commercial amorphous solid …
decade. This is evident from the number of approved commercial amorphous solid …
[HTML][HTML] Optimizing solvent selection and processing conditions to generate high bulk-density, co-precipitated amorphous dispersions of posaconazole
Co-precipitation is an emerging method to generate amorphous solid dispersions (ASDs),
notable for its ability to enable the production of ASDs containing pharmaceuticals with …
notable for its ability to enable the production of ASDs containing pharmaceuticals with …
Amorphous solid dispersion technique for improved drug delivery: basics to clinical applications
Solid dispersion has emerged as a method of choice and has been extensively investigated
to ascertain the in vivo improved performance of many drug formulations. It generally …
to ascertain the in vivo improved performance of many drug formulations. It generally …
Recent developments in dry powder inhalation (DPI) formulations for lung-targeted drug delivery
Background Dry powder inhalation (DPI) formulations have been widely studied for the
treatment of respiratory diseases, including COVID-19, which have become common and …
treatment of respiratory diseases, including COVID-19, which have become common and …
Analytical and computational methods for the determination of drug-polymer solubility and miscibility
In the pharmaceutical industry, poorly water-soluble drugs require enabling technologies to
increase apparent solubility in the biological environment. Amorphous solid dispersion …
increase apparent solubility in the biological environment. Amorphous solid dispersion …
Surface area normalized dissolution to study differences in itraconazole-copovidone solid dispersions prepared by spray-drying and hot melt extrusion
V Bhardwaj, NS Trasi, DY Zemlyanov… - International Journal of …, 2018 - Elsevier
Amorphous solid dispersions of itraconazole (ITZ) and copovidone (PVPVA 64) at 1: 1 to 1: 9
drug-polymer ratios were prepared using spray-drying (SD) and hot melt (HM) extrusion for …
drug-polymer ratios were prepared using spray-drying (SD) and hot melt (HM) extrusion for …
Critical Solvent Properties Affecting the Particle Formation Process and Characteristics of Celecoxib-Loaded PLGA Microparticles via Spray-Drying
F Wan, A Bohr, MJ Maltesen, S Bjerregaard… - Pharmaceutical …, 2013 - Springer
Purpose It is imperative to understand the particle formation mechanisms when designing
advanced nano/microparticulate drug delivery systems. We investigated how the solvent …
advanced nano/microparticulate drug delivery systems. We investigated how the solvent …
Can compression induce demixing in amorphous solid dispersions? A case study of naproxen–PVP K25
The aim of this work is to investigate the effect of compression on miscibility of naproxen
(NAP)–PVP K25 solid dispersions. Solid dispersions with diverse drug/polymer …
(NAP)–PVP K25 solid dispersions. Solid dispersions with diverse drug/polymer …