Investigation of the effects of process variables on derived properties of spray dried solid-dispersions using polymer based response surface model and ensemble …

AD Patel, A Agrawal, RH Dave - European Journal of Pharmaceutics and …, 2014 - Elsevier
The objective of this study was to use different statistical tools to understand and optimize
the spray drying process to prepare solid dispersions. In this study we investigated the …

Using acetone/water binary solvent to enhance the stability and bioavailability of spray dried enzalutamide/HPMC-AS solid dispersions

X Zhang, Q Rao, Z Qiu, Y Lin, L Zhang, Q Hu… - Journal of …, 2021 - Elsevier
We demonstrated a facile approach, by adjusting the solvent ratio of water/acetone binary
mixture, to alter the intermolecular interactions between Enzalutamide (ENZ) and …

Use of spray-dried dispersions in early pharmaceutical development: theoretical and practical challenges

J Li, D Patel, G Wang - The AAPS journal, 2017 - Springer
Spray-dried dispersions (SDDs) have become an important formulation technology for the
pharmaceutical product development of poorly water-soluble (PWS) compounds. Although …

The influence of spray-drying parameters on phase behavior, drug distribution, and in vitro release of injectable microspheres for sustained release

J Meeus, M Lenaerts, DJ Scurr, K Amssoms… - Journal of …, 2015 - Elsevier
For ternary solid dispersions, it is indispensable to characterize their structure, phase
behavior, and the spatial distribution of the dispersed drug as this might influence the …

Drug–polymer miscibility across a spray dryer: A case study of naproxen and miconazole solid dispersions

ZA Worku, J Aarts, A Singh… - Molecular …, 2014 - ACS Publications
The structural and physical stability of solid dispersions have not been adequately explored
during spray drying manufacturing processes. In this study a wide range of compositions of …

Spray-drying for the formulation of oral drug delivery systems

MPA Ferreira, JP Martins, J Hirvonen… - Nanotechnology for oral …, 2020 - Elsevier
Spray-drying is a very well established technology, used for converting emulsions,
suspensions, dispersions, or liquids into fine, dispersible particles by the use of an atomizer …

Structural characterization of amorphous solid dispersions

A Paudel, J Meeus, GV Mooter - Amorphous Solid Dispersions: Theory and …, 2014 - Springer
Amorphous solid dispersions (ASD) stand on the forefront of solubilizing formulations for
many poorly soluble drug candidates. It has been widely accepted that the physical stability …

Physical Stabilization of Pharmaceutical Glasses Based on Hydrogen Bond Reorganization under Sub-Tg Temperature

S Tominaka, K Kawakami, M Fukushima… - Molecular …, 2017 - ACS Publications
Amorphous solid dispersions (ASDs) play a key role in the pharmaceutical industry through
the use of high-energy amorphous state to improve solubility of pharmaceutical agents …

[PDF][PDF] Solid Dispersion As A Potential Approach To Improve Dissolution And Bioavailability Of Curcumin From Turmeric (Curcuma Longa L.)

R Agustina, D Setyaningsih - Int J App Pharm [Internet], 2023 - academia.edu
This review article attempts to outline techniques and solid dispersion carriers that have
been applied to improve curcumin's solubility and bioavailability in turmeric extract. This …

Spray drying of naproxen and naproxen sodium for improved tableting and dissolution–physicochemical characterization and compression performance

N Al-Zoubi, F Odeh, I Partheniadis… - Pharmaceutical …, 2021 - Taylor & Francis
In this work, the tabletability and dissolution of spray-dried forms of naproxen and its sodium
salt were compared with those of unprocessed drugs. Solutions of naproxen or naproxen …