Sex differences in cancer mechanisms

JB Rubin, JS Lagas, L Broestl, J Sponagel… - Biology of sex …, 2020 - Springer
We now know that cancer is many different diseases, with great variation even within a
single histological subtype. With the current emphasis on developing personalized …

Extracellular regulation of VEGF: isoforms, proteolysis, and vascular patterning

P Vempati, AS Popel, F Mac Gabhann - Cytokine & growth factor reviews, 2014 - Elsevier
The regulation of vascular endothelial growth factor A (VEGF) is critical to
neovascularization in numerous tissues under physiological and pathological conditions …

Recent optical sensing technologies for the detection of various biomolecules

S Kumar, R Singh - Optics & Laser Technology, 2021 - Elsevier
Various optical sensing techniques to develop different biosensors for detection of
biomolecules are summarized here. The identification of biomolecules has led to the major …

A systems biology view of blood vessel growth and remodelling

EA Logsdon, SD Finley, AS Popel… - Journal of cellular and …, 2014 - Wiley Online Library
Blood travels throughout the body in an extensive network of vessels–arteries, veins and
capillaries. This vascular network is not static, but instead dynamically remodels in response …

Effect of melatonin on tumor growth and angiogenesis in xenograft model of breast cancer

BV Jardim-Perassi, AS Arbab, LC Ferreira, TF Borin… - PloS one, 2014 - journals.plos.org
As neovascularization is essential for tumor growth and metastasis, controlling angiogenesis
is a promising tactic in limiting cancer progression. Melatonin has been studied for their …

A QSP model for predicting clinical responses to monotherapy, combination and sequential therapy following CTLA-4, PD-1, and PD-L1 checkpoint blockade

O Milberg, C Gong, M Jafarnejad, IH Bartelink… - Scientific reports, 2019 - nature.com
Over the past decade, several immunotherapies have been approved for the treatment of
melanoma. The most prominent of these are the immune checkpoint inhibitors, which are …

An easy way to realize SPR aptasensor: A multimode plastic optical fiber platform for cancer biomarkers detection

N Cennamo, M Pesavento, L Lunelli, L Vanzetti… - Talanta, 2015 - Elsevier
The introduction of new compact systems for sensitive, fast and simplified analysis is
currently playing a substantial role in the development of point-of-care solutions aimed to …

[HTML][HTML] Targeting VEGF signalling via the neuropilin co-receptor

S Djordjevic, PC Driscoll - Drug discovery today, 2013 - Elsevier
The blockade of tumour vascularisation and angiogenesis continues to be a focus for drug
development in oncology and other pathologies. Historically, targeting vascular endothelial …

VEGFR1 promotes cell migration and proliferation through PLCγ and PI3K pathways

JC Weddell, S Chen, PI Imoukhuede - NPJ systems biology and …, 2017 - nature.com
The ability to control vascular endothelial growth factor (VEGF) signaling offers promising
therapeutic potential for vascular diseases and cancer. Despite this promise, VEGF-targeted …

Effect of tumor microenvironment on tumor VEGF during anti-VEGF treatment: systems biology predictions

SD Finley, AS Popel - JNCI: Journal of the National Cancer …, 2013 - academic.oup.com
Background Vascular endothelial growth factor (VEGF) is known to be a potent promoter of
angiogenesis under both physiological and pathological conditions. Given its role in …