Sex differences in cancer mechanisms
JB Rubin, JS Lagas, L Broestl, J Sponagel… - Biology of sex …, 2020 - Springer
We now know that cancer is many different diseases, with great variation even within a
single histological subtype. With the current emphasis on developing personalized …
single histological subtype. With the current emphasis on developing personalized …
Extracellular regulation of VEGF: isoforms, proteolysis, and vascular patterning
P Vempati, AS Popel, F Mac Gabhann - Cytokine & growth factor reviews, 2014 - Elsevier
The regulation of vascular endothelial growth factor A (VEGF) is critical to
neovascularization in numerous tissues under physiological and pathological conditions …
neovascularization in numerous tissues under physiological and pathological conditions …
Recent optical sensing technologies for the detection of various biomolecules
Various optical sensing techniques to develop different biosensors for detection of
biomolecules are summarized here. The identification of biomolecules has led to the major …
biomolecules are summarized here. The identification of biomolecules has led to the major …
A systems biology view of blood vessel growth and remodelling
Blood travels throughout the body in an extensive network of vessels–arteries, veins and
capillaries. This vascular network is not static, but instead dynamically remodels in response …
capillaries. This vascular network is not static, but instead dynamically remodels in response …
Effect of melatonin on tumor growth and angiogenesis in xenograft model of breast cancer
As neovascularization is essential for tumor growth and metastasis, controlling angiogenesis
is a promising tactic in limiting cancer progression. Melatonin has been studied for their …
is a promising tactic in limiting cancer progression. Melatonin has been studied for their …
A QSP model for predicting clinical responses to monotherapy, combination and sequential therapy following CTLA-4, PD-1, and PD-L1 checkpoint blockade
Over the past decade, several immunotherapies have been approved for the treatment of
melanoma. The most prominent of these are the immune checkpoint inhibitors, which are …
melanoma. The most prominent of these are the immune checkpoint inhibitors, which are …
An easy way to realize SPR aptasensor: A multimode plastic optical fiber platform for cancer biomarkers detection
The introduction of new compact systems for sensitive, fast and simplified analysis is
currently playing a substantial role in the development of point-of-care solutions aimed to …
currently playing a substantial role in the development of point-of-care solutions aimed to …
[HTML][HTML] Targeting VEGF signalling via the neuropilin co-receptor
S Djordjevic, PC Driscoll - Drug discovery today, 2013 - Elsevier
The blockade of tumour vascularisation and angiogenesis continues to be a focus for drug
development in oncology and other pathologies. Historically, targeting vascular endothelial …
development in oncology and other pathologies. Historically, targeting vascular endothelial …
VEGFR1 promotes cell migration and proliferation through PLCγ and PI3K pathways
JC Weddell, S Chen, PI Imoukhuede - NPJ systems biology and …, 2017 - nature.com
The ability to control vascular endothelial growth factor (VEGF) signaling offers promising
therapeutic potential for vascular diseases and cancer. Despite this promise, VEGF-targeted …
therapeutic potential for vascular diseases and cancer. Despite this promise, VEGF-targeted …
Effect of tumor microenvironment on tumor VEGF during anti-VEGF treatment: systems biology predictions
Background Vascular endothelial growth factor (VEGF) is known to be a potent promoter of
angiogenesis under both physiological and pathological conditions. Given its role in …
angiogenesis under both physiological and pathological conditions. Given its role in …