Superparamagnetic iron oxide nanoparticles (SPIONs): development, surface modification and applications in chemotherapy

M Mahmoudi, S Sant, B Wang, S Laurent… - Advanced drug delivery …, 2011 - Elsevier
At present, nanoparticles are used for various biomedical applications where they facilitate
laboratory diagnostics and therapeutics. More specifically for drug delivery purposes, the …

Interactions of nanomaterials and biological systems: Implications to personalized nanomedicine

XQ Zhang, X Xu, N Bertrand, E Pridgen… - Advanced drug delivery …, 2012 - Elsevier
The application of nanotechnology to personalized medicine provides an unprecedented
opportunity to improve the treatment of many diseases. Nanomaterials offer several …

Clinical imaging in regenerative medicine

AV Naumova, M Modo, A Moore, CE Murry… - Nature …, 2014 - nature.com
In regenerative medicine, clinical imaging is indispensable for characterizing damaged
tissue and for measuring the safety and efficacy of therapy. However, the ability to track the …

Stem cell therapy as an emerging paradigm for stroke (STEPS) II

SI Savitz, M Chopp, R Deans, ST Carmichael… - Stroke, 2011 - Am Heart Assoc
Cell-based therapies represent a new therapeutic approach for stroke. In 2007, investigators
from academia, industry leaders, and members of the National Institutes of Health crafted …

Self-assembling nanocomplexes by combining ferumoxytol, heparin and protamine for cell tracking by magnetic resonance imaging

MS Thu, LH Bryant, T Coppola, EK Jordan… - Nature medicine, 2012 - nature.com
We report on a new straightforward magnetic cell-labeling approach that combines three US
Food and Drug Administration (FDA)-approved drugs—ferumoxytol, heparin and protamine …

Inorganic nanoparticles for image-guided therapy

HY Yoon, S Jeon, DG You, JH Park, IC Kwon… - Bioconjugate …, 2017 - ACS Publications
Recently, nanotechnology has provided significant advances in biomedical applications
including diagnosis and therapy. In particular, nanoparticles have emerged as valuable …

Superparamagnetic iron oxide nanoparticles for direct labeling of stem cells and in vivo MRI tracking

SJ Kim, B Lewis, MS Steiner, UV Bissa… - Contrast media & …, 2016 - Wiley Online Library
To develop effective stem cell therapies, it is important to track therapeutic cells non‐
invasively and monitor homing to areas of pathology. The purpose of this study was to …

Ferumoxytol: a new, clinically applicable label for stem-cell tracking in arthritic joints with MRI

A Khurana, H Nejadnik, F Chapelin, O Lenkov… - …, 2013 - Future Medicine
Aim: To develop a clinically applicable MRI technique for tracking stem cells in matrix-
associated stem-cell implants, using the US FDA-approved iron supplement ferumoxytol …

Iron administration before stem cell harvest enables MR imaging tracking after transplantation

A Khurana, F Chapelin, G Beck, OD Lenkov, J Donig… - Radiology, 2013 - pubs.rsna.org
Purpose To determine whether intravenous ferumoxytol can be used to effectively label
mesenchymal stem cells (MSCs) in vivo and can be used for tracking of stem cell …

Umbilical cord blood mononuclear cell transplantation for neonatal hypoxic–ischemic encephalopathy

PM Pimentel-Coelho, PH Rosado-de-Castro… - Pediatric …, 2012 - nature.com
Despite recent advances in the treatment of neonatal hypoxic–ischemic encephalopathy
(HIE) using therapeutic hypothermia, at least 30% of the cooled infants will die or have …