Overweight and obesity represent major risk factors for diabetes and related metabolic
diseases. Obesity is associated with a chronic and progressive inflammatory response …

Importance Early-onset Alzheimer disease (EOAD) is a rare form of Alzheimer disease (AD)
with a large genetic basis that is only partially understood. In late-onset AD, elevated …

Background and aims Abdominal aortic aneurysm (AAA) is an important cause of death
worldwide and has an estimated heritability between 70 and 77%. Genome-wide …

PCSK9 is a secreted protein that regulates plasma cholesterol levels and cardiovascular
disease risk. Prior studies suggested the presence of an ER cargo receptor that recruits …

Background DNA methylation profiles are responsive to environmental stimuli and metabolic
shifts. This makes DNA methylation a potential biomarker of environmental-related and …

Background The APOA5 rs662799 polymorphism has been widely reported regarding its
associations with the plasma lipid levels and the occurrence of coronary heart disease …

Dyslipidemias are common risk factors for the development of chronic disorders including
type 2 diabetes (T2D). Over 100 associated loci have been identified but few reports have …

Background Lysosomal acid lipase deficiency (LALD) is an autosomal recessive inborn
error of lipid metabolism characterized by impaired lysosomal hydrolysis and consequent …

Low levels of high density lipoprotein-cholesterol (HDL-C) are associated with an elevated
risk of arteriosclerotic coronary heart disease. Heritability of HDL-C levels is high. In this …

Background Solid evidence indicates that intake of marine n-3 fatty acids lowers serum
triglycerides and that replacing saturated fatty acids (SFA) with polyunsaturated fatty acids …