Inflammatory pathophysiology as a contributor to myeloproliferative neoplasms

DAC Fisher, JS Fowles, A Zhou, ST Oh - Frontiers in immunology, 2021 - frontiersin.org
Myeloid neoplasms, including acute myeloid leukemia (AML), myeloproliferative neoplasms
(MPNs), and myelodysplastic syndromes (MDS), feature clonal dominance and remodeling …

Novel mutations and their functional and clinical relevance in myeloproliferative neoplasms: JAK2, MPL, TET2, ASXL1, CBL, IDH and IKZF1

A Tefferi - Leukemia, 2010 - nature.com
Myeloproliferative neoplasms (MPNs) originate from genetically transformed hematopoietic
stem cells that retain the capacity for multilineage differentiation and effective myelopoiesis …

Mutations and prognosis in primary myelofibrosis

AM Vannucchi, TL Lasho, P Guglielmelli, F Biamonte… - Leukemia, 2013 - nature.com
Patient outcome in primary myelofibrosis (PMF) is significantly influenced by karyotype. We
studied 879 PMF patients to determine the individual and combinatorial prognostic …

DIPSS plus: a refined Dynamic International Prognostic Scoring System for primary myelofibrosis that incorporates prognostic information from karyotype, platelet …

N Gangat, D Caramazza, R Vaidya… - Journal of Clinical …, 2011 - ascopubs.org
Purpose The Dynamic International Prognostic Scoring System (DIPSS) for primary
myelofibrosis (PMF) uses five risk factors to predict survival: age older than 65 years …

Safety and efficacy of INCB018424, a JAK1 and JAK2 inhibitor, in myelofibrosis

S Verstovsek, H Kantarjian, RA Mesa… - … England Journal of …, 2010 - Mass Medical Soc
Background Myelofibrosis is a Philadelphia chromosome–negative myeloproliferative
neoplasm associated with cytopenias, splenomegaly, poor quality of life, and shortened …

Philadelphia-negative classical myeloproliferative neoplasms: critical concepts and management recommendations from European LeukemiaNet

T Barbui, G Barosi, G Birgegard, F Cervantes… - Journal of clinical …, 2011 - ascopubs.org
We present a review of critical concepts and produce recommendations on the management
of Philadelphia-negative classical myeloproliferative neoplasms, including monitoring …

A dynamic prognostic model to predict survival in primary myelofibrosis: a study by the IWG-MRT (International Working Group for Myeloproliferative Neoplasms …

F Passamonti, F Cervantes… - Blood, The Journal …, 2010 - ashpublications.org
Age older than 65 years, hemoglobin level lower than 100 g/L (10 g/dL), white blood cell
count greater than 25× 109/L, peripheral blood blasts 1% or higher, and constitutional …

Survival and disease progression in essential thrombocythemia are significantly influenced by accurate morphologic diagnosis: an international study

T Barbui, J Thiele, F Passamonti, E Rumi… - Journal of clinical …, 2011 - ascopubs.org
Purpose The WHO diagnostic criteria underscore the role of bone marrow (BM) morphology
in distinguishing essential thrombocythemia (ET) from early/prefibrotic primary myelofibrosis …

Primary myelofibrosis: 2017 update on diagnosis, risk‐stratification, and management

A Tefferi - American journal of hematology, 2016 - Wiley Online Library
Disease overview: Primary myelofibrosis (PMF) is a myeloproliferative neoplasm (MPN)
characterized by stem cell‐derived clonal myeloproliferation that is often but not always …

A prospective study of 338 patients with polycythemia vera: the impact of JAK2 (V617F) allele burden and leukocytosis on fibrotic or leukemic disease transformation …

F Passamonti, E Rumi, D Pietra, C Elena, E Boveri… - Leukemia, 2010 - nature.com
We studied the relationship between JAK2 (V617F) mutant allele burden and clinical
phenotype, disease progression and survival in patients with polycythemia vera (PV). The …