The formation of the embryonic brain and spinal cord begins as the neural plate bends to
form the neural folds, which meet and adhere to close the neural tube. The neural ectoderm …

Neural tube defects (NTDs) represent a failure of the neural plate to complete the
developmental transition to a neural tube. NTDs are the most common birth anomaly of the …

Copy number variants (CNVs) represent a frequent type of lesion in human genetic
disorders that typically affects numerous genes simultaneously. This has raised the …

Neural tube defects are the most severe congenital malformations that result from failure of
neural tube closure during early embryonic development, and the underlying molecular …

Wnt signaling plays a major role in early neural development. An aberrant activation in
Wnt/β-catenin pathway causes defective anteroposterior patterning, which results in neural …

Increasing evidence that mutation of planar cell polarity (PCP) genes contributes to human
cranial neural tube defect (NTD) susceptibility prompted us to hypothesize that rare variants …

Purpose Next-generation sequencing has implicated some risk variants for human spina
bifida (SB), but the genome-wide contribution of structural variation to this complex genetic …

Retinoic acid (RA), an active derivative of vitamin A, is critical for the neural system
development. During the neural development, the RA/RA receptor (RAR) pathway …

The search for genetic determinants of human neural tube def... : Current Opinion in
Pediatrics The search for genetic determinants of human neural tube defects : Current …

Myelomeningocele (MMC) affects one in 1000 newborns annually worldwide and each
surviving child faces tremendous lifetime medical and caregiving burdens. Both genetic and …