Bloodstream infections (BSI) have a substantial impact on morbidity and mortality worldwide.
Despite scarcity of data from many low-and middle-income countries (LMICs), there is …

Background Mortality and other clinical outcomes between culture-negative and culture-
positive septic patients have been documented inconsistently and are very controversial. A …

Background: Administering antimicrobial agents before obtaining blood cultures could
potentially decrease time to treatment and improve outcomes, but it is unclear how this …

Abstract The Centers for Medicare & Medicaid Services' Severe Sepsis and Septic Shock
Early Management Bundle (SEP-1) measure has appropriately established sepsis as a …

Background Microbial cell-free DNA (mcfDNA) sequencing of plasma can identify the
presence of a pathogen in a host. In this study, we evaluated the duration of pathogen …

Antimicrobial resistance (AMR) has been exacerbated by the inappropriate use of
diagnostics, leading to excessive prescription of antimicrobials, and is an imminent threat to …

Financial Disclosure Dr. Shields is the Principal Investigator of an AHRQ grant for
developing a simulation course on maternal cardiac arrest; provided volunteer expert …

Importance Gram staining should provide immediate information for detecting causative
pathogens. However, the effect of Gram staining on restricting the initial antibiotic choice has …

The neutrophil–lymphocyte ratio (NLR) is an emerging risk factor of sepsis that is receiving
increasing attention. However, the relationship between NLR and the presence of sepsis in …

Sepsis globally accounts for an alarming annual toll of 48.9 million cases, resulting in 11
million deaths, and inflicts an economic burden of approximately USD 38 billion on the …