[HTML][HTML] Single-prolonged stress: a review of two decades of progress in a rodent model of post-traumatic stress disorder

MJ Lisieski, AL Eagle, AC Conti, I Liberzon… - Frontiers in …, 2018 - frontiersin.org
Post-traumatic stress disorder (PTSD) is a common, costly, and often debilitating psychiatric
condition. However, the biological mechanisms underlying this disease are still largely …

[HTML][HTML] Autophagy: roles in intestinal mucosal homeostasis and inflammation

S Haq, J Grondin, S Banskota, WI Khan - Journal of Biomedical Science, 2019 - Springer
The intestinal mucosa is a site of multiple stressors and forms the barrier between the
internal and external environment. In the intestine, a complex interplay between the …

Disruption of autophagy by increased 5-HT alters gut microbiota and enhances susceptibility to experimental colitis and Crohn's disease

S Haq, H Wang, J Grondin, S Banskota, JK Marshall… - Science …, 2021 - science.org
Autophagy, an essential intracellular recycling process, is linked to the pathogenesis of
various diseases including Crohn's disease (CD). Factors that lead to the development of …

The therapeutic and diagnostic potential of the prostate specific membrane antigen/glutamate carboxypeptidase II (PSMA/GCPII) in cancer and neurological disease

JC Evans, M Malhotra, JF Cryan… - British journal of …, 2016 - Wiley Online Library
Prostate specific membrane antigen (PSMA) otherwise known as glutamate
carboxypeptidase II (GCPII) is a membrane bound protein that is highly expressed in …

[HTML][HTML] Neurobiology of anorexia nervosa: serotonin dysfunctions link self-starvation with body image disturbances through an impaired body memory

G Riva - Frontiers in human neuroscience, 2016 - frontiersin.org
The etiology of anorexia nervosa (AN) is still unclear, despite that it is a critical and
potentially mortal illness. A recent neurobiological model considers AN as the outcome of …

Role of apoptosis in the Post-traumatic stress disorder model-single prolonged stressed rats

Y Jia, Y Han, X Wang, F Han - Psychoneuroendocrinology, 2018 - Elsevier
Post-traumatic stress disorder (PTSD) is a stress-related mental disorder which occurs
following exposure to traumatic events. A number of brain neuroimaging studies have …

New neurons restore structural and behavioral abnormalities in a rat model of PTSD

TJ Schoenfeld, D Rhee, L Martin, JA Smith… - …, 2019 - Wiley Online Library
Post‐traumatic stress disorder (PTSD) has been associated with anxiety, memory
impairments, enhanced fear, and hippocampal volume loss, although the relationship …

Glycyrrhizin treatment facilitates extinction of conditioned fear responses after a single prolonged stress exposure in rats

S Lai, G Wu, Z Jiang - Cellular Physiology and Biochemistry, 2018 - karger.com
Abstract Background/Aims: Impaired fear memory extinction is widely considered a key
mechanism of post-traumatic stress disorder (PTSD). Recent studies have suggested that …

Sensitivity to trauma-associated cues is restricted to vulnerable traumatized rats and reinstated after extinction by yohimbine

C Le Dorze, P Gisquet-Verrier - Behavioural brain research, 2016 - Elsevier
While post-traumatic stress disorder (PTSD) symptom is mainly characterized by re-
experiencing the traumatic event, the reactivity to trauma-associated cues in resilient and …

Revisiting the behavioral genetics of serotonin: relevance to anxiety and depression

OF O'Leary, MG Codagnone, JF Cryan - Handbook of behavioral …, 2020 - Elsevier
hydroxytryptamine (5-HT, serotonin) is a major neurotransmitter involved in the modulation
of behavior and the manifestation of various psychiatric disorders, and is a pharmacological …