Hematopoietic stem cell (HSC) generation in the aorta-gonad-mesonephros region requires
HSC specification signals from the surrounding microenvironment. In zebrafish, PDGF …

The interactions of stromal cells with hematopoietic cells in the bone marrow have long been
a subject of research, but only recently have technologies allowed us to dissect them at the …

Myeloproliferative neoplasms (MPNs) are hematopoietic stem cell disorders with
dysregulated myeloid blood cell production and propensity for transformation to acute …

Uncovering the cellular and molecular mechanisms by which hematopoietic stem cell (HSC)
self-renewal is regulated can lead to the development of new strategies for promoting ex …

Healthy aging depends on a complex gene-environment network that is ultimately reflected
in the expression of different proteins. We aimed to perform a comparative analysis of the …

Hematopoietic stem cells (HSC) are responsible for the production of blood and immune
cells during life. HSC fate decisions are dependent on signals from specialized …

Mesenchymal stromal cells (MSCs) have, for a long time, been recognized as pivotal
contributors in the set up and maintenance of the hematopoietic stem cell (HSC) niche, as …

The musculoskeletal system includes tissues that have remarkable regenerative
capabilities. Bone and muscle sustain micro-damage throughout the lifetime, yet they …

While two-dimensional (2D) monolayers of mesenchymal stem/stromal cells (MSCs) have
been shown to enhance hematopoietic stem/progenitor cell (HSPC) expansion in vitro …

The interest in perivascular cells as a niche for adult hematopoietic stem cells (HSCs) is
significantly growing. In the adult bone marrow (BM), perivascular cells and HSCs cohabit …