Background aims Human mesenchymal stromal cells (MSCs) are being used in clinical
trials, but the best protocol to prepare the cells for administration to patients remains unclear …

B-cell acute lymphoblastic leukemia (B-ALL) results from the expansion of malignant
lymphoid precursors within the bone marrow (BM), where hematopoietic niches and …

Modeling the interaction between the supportive stroma and the hematopoietic stem and
progenitor cells (HSPC) is of high interest in the regeneration of the bone marrow niche in …

In many leukemia patients, a poor prognosis is attributed either to the development of
chemotherapy resistance by leukemic stem cells (LSCs) or to the inefficient engraftment of …

Executioner caspase-3 and-7 are proteases promoting cell death but non-apoptotic roles
are being discovered. The heart expresses caspases only during development, suggesting …

Bone marrow mesenchymal stromal cells (BM-MSCs) are a rare population of cells that
gives rise to skeletal tissues and the hematopoietic stroma in vivo. Recently, we have …

Recent discoveries have significantly expanded our previous knowledge about the role of
bone marrow mesenchymal stem cells (BMSCs) in hematopoiesis. BMSCs and their …

Human bone marrow contains a population of non-hematopoietic stromal stem/progenitor
cells (BMSCs), which play a central role for bone marrow stroma and the hematopoietic …

Mesenchymal stromal cells (MSCs) show potential for treating cardiovascular diseases, but
their therapeutic efficacy exhibits significant heterogeneity depending on the tissue of origin …

The bone marrow (BM) tissue is the main physiological site for adult hematopoiesis. In
recent years, the cellular and matrix components composing the BM have been defined with …