The hematology of tomorrow is here—preclinical models are not: cell therapy for hematological malignancies

L Arranz - Cancers, 2022 - mdpi.com
Simple Summary Cell therapy is revolutionizing the prospect of deadly hematological
malignancies such as high-risk acute myeloid leukemia. Stem cell therapy of allogeneic …

Human CD34loCD133lo fetal liver cells support the expansion of human CD34hiCD133hi hematopoietic stem cells

KSM Yong, CT Keng, SQ Tan, E Loh… - Cellular & molecular …, 2016 - nature.com
We have recently discovered a unique CD34 lo CD133 lo cell population in the human fetal
liver (FL) that gives rise to cells in the hepatic lineage. In this study, we further characterized …

The human and murine hematopoietic stem cell niches: are they comparable?

M van Pel, WE Fibbe, K Schepers - Annals of the New York …, 2016 - Wiley Online Library
Hematopoietic stem cells (HSCs) reside in specific niches that provide various instructive
cues that regulate HSC self‐renewal and their development into all mature cells of the …

Towards the Identification and Characterization of Putative Adult Human Lens Epithelial Stem Cells

P Saranya, M Shekhar, A Haripriya, V Muthukkaruppan… - Cells, 2023 - mdpi.com
The anterior lens epithelium has the ability to differentiate into lens fibres throughout its life.
The present study aims to identify and functionally characterize the adult stem cells in the …

[HTML][HTML] Autonomic regulation of hematopoiesis and cancer

R del Toro, S Méndez-Ferrer - Haematologica, 2013 - ncbi.nlm.nih.gov
The functions of the autonomic nervous system have expanded in the last years from 'fight-or-
flight'responses to fine-tuned control of multiple homeostatic and pathological processes …

Inferring gene networks in bone marrow hematopoietic stem cell-supporting stromal niche populations

C Desterke, L Petit, N Sella, N Chevallier, V Cabeli… - IScience, 2020 - cell.com
The cardinal property of bone marrow (BM) stromal cells is their capacity to contribute to
hematopoietic stem cell (HSC) niches by providing mediators assisting HSC functions. In …

Hematopoietic–mesenchymal signals regulate the properties of mesenchymal stem cells

S Kanazawa, H Okada, D Riu, Y Mabuchi… - International journal of …, 2022 - mdpi.com
It is well known that the properties of hematopoietic stem/progenitor cells (HSCs), such as
their self-renewal ability and multipotency, are maintained through interactions with …

Mesenchymal Stem Cells in Autoimmune Disease: A Systematic Review and Meta-Analysis of Pre-Clinical Studies

HN Swain, PD Boyce, BA Bromet, K Barozinksy… - Biochimie, 2024 - Elsevier
ABSTRACT Mesenchymal Stem Cells (MSCs) are of interest in the clinic because of their
immunomodulation capabilities, capacity to act upstream of inflammation, and ability to …

Extra-hematopoietic immunomodulatory role of the guanine-exchange factor DOCK2

C Scharler, R Poupardin, P Ebner-Peking… - Communications …, 2022 - nature.com
Stromal cells interact with immune cells during initiation and resolution of immune
responses, though the precise underlying mechanisms remain to be resolved. Lessons …

Enhanced hematopoietic stem cell self-renewal-promoting ability of clonal primary mesenchymal stromal/stem cells versus their osteogenic progeny

Q He, C Scott Swindle, C Wan, RJ Flynn, RA Oster… - Stem Cells, 2017 - academic.oup.com
Long-term self-renewing hematopoietic stem cell (LT-HSC) homeostasis within the bone
marrow (BM) of adult mammals is regulated by complex interactions between LT-HSC and a …