Exosomes─ nature's lipid nanoparticles, a rising star in drug delivery and diagnostics

R Tenchov, JM Sasso, X Wang, WS Liaw, CA Chen… - ACS …, 2022 - ACS Publications
Exosomes are a subgroup of nanosized extracellular vesicles enclosed by a lipid bilayer
membrane and secreted by most eukaryotic cells. They represent a route of intercellular …

Aptamer-based detection of circulating targets for precision medicine

L Wu, Y Wang, X Xu, Y Liu, B Lin, M Zhang… - Chemical …, 2021 - ACS Publications
The past decade has witnessed ongoing progress in precision medicine to improve human
health. As an emerging diagnostic technique, liquid biopsy can provide real-time …

Exosome: a review of its classification, isolation techniques, storage, diagnostic and targeted therapy applications

Y Zhang, J Bi, J Huang, Y Tang, S Du… - International journal of …, 2020 - Taylor & Francis
Exosomes are nano-sized small extracellular vesicles secreted by cells, carrying nucleic
acids, proteins, lipids and other bioactive substances to play a role in the body's …

[HTML][HTML] Release mechanisms of major DAMPs

A Murao, M Aziz, H Wang, M Brenner, P Wang - Apoptosis, 2021 - Springer
Damage-associated molecular patterns (DAMPs) are endogenous molecules which foment
inflammation and are associated with disorders in sepsis and cancer. Thus, therapeutically …

[HTML][HTML] The role of exosomes and their applications in cancer

Y Zhou, Y Zhang, H Gong, S Luo, Y Cui - International journal of …, 2021 - mdpi.com
Exosomes are very small extracellular vesicles secreted by multiple cell types and are
extensively distributed in various biological fluids. Recent research indicated that exosomes …

Tumor-derived extracellular vesicles: The metastatic organotropism drivers

J Rezaie, M Ahmadi, R Ravanbakhsh, B Mojarad… - Life Sciences, 2022 - Elsevier
The continuous growing, spreading, and metastasis of tumor cells depend on intercellular
communication within cells resident in a tissue environment. Such communication is …

Application of extracellular vesicles derived from mesenchymal stem cells as potential therapeutic tools in autoimmune and rheumatic diseases

H Huldani, SA Jasim, DO Bokov… - International …, 2022 - Elsevier
Mesenchymal stem cells (MSCs) have been proven to have superior potential to be used as
therapeutic candidates in various disorders. Nevertheless, the clinical application of these …

Microfluidic‐based exosome analysis for liquid biopsy

B Lin, Y Lei, J Wang, L Zhu, Y Wu, H Zhang… - Small …, 2021 - Wiley Online Library
Liquid biopsy offers non‐invasive and real‐time molecular profiling of individual patients,
and is thus considered a revolutionary technology in precision medicine. Exosomes have …

Current advances in the use of exosomes, liposomes, and bioengineered hybrid nanovesicles in cancer detection and therapy

A Mukherjee, B Bisht, S Dutta, MK Paul - Acta Pharmacologica Sinica, 2022 - nature.com
Three major approaches of cancer therapy can be enunciated as delivery of biotherapeutics,
tumor image analysis, and immunotherapy. Liposomes, artificial fat bubbles, are long known …

[HTML][HTML] Targeted inhibition of tumor-derived exosomes as a novel therapeutic option for cancer

Y Li, ZK Chen, X Duan, HJ Zhang, BL Xiao… - … & molecular medicine, 2022 - nature.com
Mounting evidence indicates that tumor-derived exosomes (TDEs) play critical roles in tumor
development and progression by regulating components in the tumor microenvironment …