Background Knee replacements are the mainstay of treatment for end-stage osteoarthritis
and are effective. Given time, all knee replacements will fail and knowing when this failure …

The purpose of this article is to provide a synopsis of the current medical understanding of
knee osteoarthritis. We describe the prevalence, causes and associated risk factors …

Background Total joint replacements for end-stage osteoarthritis of the hip and knee are cost-
effective and demonstrate significant clinical improvement. However, robust population …

Background More than 670,000 total knee replacements are performed annually in the
United States; however, high-quality evidence to support the effectiveness of the procedure …

Objective To present a clear and comprehensive summary of the published data on
unicompartmental knee replacement (UKA) or total knee replacement (TKA), comparing …

Background The number of revision Total Knee Arthroplasty (TKA) is rising in many
countries. The aim of this study was the prospective assessment of the underlying causes …

Purpose To use meta-analysis techniques to evaluate the efficacy and safety of platelet-rich
plasma (PRP) injections for the treatment knee of osteoarthritis (OA). Methods We performed …

Objective To estimate the future rate of primary total hip (THR) or knee (TKR) replacement in
the UK to 2035 allowing for changes in population demographics and obesity. Design Using …

Osteoarthritis (OA) is the leading form of arthritis in the elderly, causing pain, disability, and
immobility. OA has been associated with accumulation of senescent cells in or near joints …

Context Total knee arthroplasty (TKA) is one of the most common and costly surgical
procedures performed in the United States. Objective To examine longitudinal trends in …