Proteomics, personalized medicine and cancer
Simple Summary Cancer, a major public health issue worldwide, is the second most
common cause of death. Initiatives such as the Human Genome Project (HGP) and Human …
common cause of death. Initiatives such as the Human Genome Project (HGP) and Human …
Landscape of tumor suppressor mutations in acute myeloid leukemia
C Panuzzo, E Signorino, C Calabrese, MS Ali… - Journal of clinical …, 2020 - mdpi.com
Acute myeloid leukemia is mainly characterized by a complex and dynamic genomic
instability. Next-generation sequencing has significantly improved the ability of diagnostic …
instability. Next-generation sequencing has significantly improved the ability of diagnostic …
Active Akt signaling triggers CLL toward Richter transformation via overactivation of Notch1
V Kohlhaas, SJ Blakemore, M Al-Maarri… - Blood, The Journal …, 2021 - ashpublications.org
Richter's transformation (RT) is an aggressive lymphoma that occurs upon progression from
chronic lymphocytic leukemia (CLL). Transformation has been associated with genetic …
chronic lymphocytic leukemia (CLL). Transformation has been associated with genetic …
Proteomic and phosphoproteomic landscapes of acute myeloid leukemia
MH Kramer, Q Zhang, R Sprung, RB Day… - Blood, The Journal …, 2022 - ashpublications.org
We have developed a deep-scale proteome and phosphoproteome database from 44
representative acute myeloid leukemia (AML) patients from the LAML TCGA dataset and 6 …
representative acute myeloid leukemia (AML) patients from the LAML TCGA dataset and 6 …
S100A4 in the Physiology and Pathology of the Central and Peripheral Nervous System
N D'Ambrosi, M Milani, S Apolloni - Cells, 2021 - mdpi.com
S100A4 is a member of the large family of S100 proteins, exerting a broad range of
intracellular and extracellular functions that vary upon different cellular contexts. While …
intracellular and extracellular functions that vary upon different cellular contexts. While …
Long noncoding RNAs have pivotal roles in chemoresistance of acute myeloid leukemia
Many patients with acute myeloid leukemia (AML) experience poor outcomes following
traditional high-dose chemotherapies and complete remission rates remain suboptimal …
traditional high-dose chemotherapies and complete remission rates remain suboptimal …
The correlation between proteoglycan 2 and neuropsychiatric systemic lupus erythematosus
X Qiao, L Lu, K Zhou, L Tan, X Liu, J Ni, Y Hou… - Clinical …, 2022 - Elsevier
The proposed pathogenesis of neuropsychiatric systemic lupus erythematosus (NPSLE)
mainly includes ischemia and neuroinflammation mechanisms. Protein encoded by …
mainly includes ischemia and neuroinflammation mechanisms. Protein encoded by …
[PDF][PDF] Isoform-specific and signaling-dependent propagation of acute myeloid leukemia by Wilms tumor 1
Acute myeloid leukemia (AML) is caused by recurrent mutations in members of the gene
regulatory and signaling machinery that control hematopoietic progenitor cell growth and …
regulatory and signaling machinery that control hematopoietic progenitor cell growth and …
Advancements in oncoproteomics technologies: treading toward translation into clinical practice
Proteomics continues to forge significant strides in the discovery of essential biological
processes, uncovering valuable information on the identity, global protein abundance …
processes, uncovering valuable information on the identity, global protein abundance …
Exosomes from BM-MSCs promote acute myeloid leukemia cell proliferation, invasion and chemoresistance via upregulation of S100A4
T Lyu, Y Wang, D Li, H Yang, B Qin, W Zhang… - … Hematology & Oncology, 2021 - Springer
Background BM-MSCs play an important role in cancer development through the release of
cytokines or exosomes. Studies have shown that extracellular exosomes derived from BM …
cytokines or exosomes. Studies have shown that extracellular exosomes derived from BM …