[HTML][HTML] Asymmetric synthesis of organophosphorus compounds using H–P reagents derived from chiral alcohols

JD Gbubele, TK Olszewski - Organic & Biomolecular Chemistry, 2021 - pubs.rsc.org
Chiral organophosphorus compounds, especially those containing C-stereogenic carbons
in the proximity of the phosphorus atom, are known for their unique properties and have …

[HTML][HTML] Recent advances in the synthesis of ibuprofen and naproxen

MW Ha, SM Paek - Molecules, 2021 - mdpi.com
Herein, we review the recent progress in the synthesis of representative nonsteroidal anti-
inflammatory drugs (NSAIDs), ibuprofen and naproxen. Although these drugs were …

TBADT‐Mediated Photocatalytic Stereoselective Radical Alkylation of Chiral N‐Sulfinyl Imines: Towards Efficient Synthesis of Diverse Chiral Amines

M Leone, JP Milton, D Gryko, L Neuville… - … –A European Journal, 2024 - Wiley Online Library
Herein we describe a sustainable and efficient photocatalytic method for the stereoselective
radical alkylation of chiral sulfinyl imines. By employing readily available non …

Ultrasonic energy for construction of bioactive heterocycles

O Kamble, R Chatterjee, R Dandela, S Shinde - Tetrahedron, 2022 - Elsevier
The ultrasonic energy has been revisited and applied for the synthesis of bioactive
molecules in a short time and green method. These compounds can exhibit anticancer …

Interrupted Pyridine Hydrogenation: Asymmetric Synthesis of δ‐Lactams

T Wagener, L Lückemeier, CG Daniliuc… - Angewandte Chemie …, 2021 - Wiley Online Library
Metal‐catalyzed hydrogenation is an effective method to transform readily available arenes
into saturated motifs, however, current hydrogenation strategies are limited to the formation …

Oxazolidinones as chiral auxiliaries in asymmetric aldol reaction applied to natural products total synthesis

A Nazari, MM Heravi, V Zadsirjan - Journal of Organometallic Chemistry, 2021 - Elsevier
The aldol condensation is one of the most important CC bond formation strategies in the art
of organic synthesis. Its asymmetric variant, so-called, aldol reaction has found several …

[HTML][HTML] Organophotocatalytic dearomatization of indoles, pyrroles and benzo (thio) furans via a Giese-type transformation

Y Zhang, P Ji, F Gao, Y Dong, H Huang… - Communications …, 2021 - nature.com
Accessing fascinating organic and biological significant indolines via dearomatization of
indoles represents one of the most efficient approaches. However, it has been difficult for the …

Thiazolidinediones: an in–depth study of their synthesis and application to medicinal chemistry in the treatment of diabetes mellitus

N Long, A Le Gresley, SP Wren - ChemMedChem, 2021 - Wiley Online Library
Thiazolidinedione (TZD) is a privileged and highly utilised scaffold for the development of
pharmaceutically active compounds. This sulfur‐containing heterocycle is a versatile …

Asymmetric Hydrative Aldol Reaction (HAR) via Vinyl‐Gold Promoted Intermolecular Ynamide Addition to Aldehydes

T Yuan, K Radefeld, C Shan, C Wegner… - Angewandte Chemie …, 2023 - Wiley Online Library
Herein, we reported an intermolecular asymmetric hydrative aldol reaction through vinyl‐
gold intermediate under ambient conditions. This tandem alkyne hydration and sequential …

Boron Catalysis in the Transformation of Carboxylic Acids and Carboxylic Acid Derivatives

M Sawamura, Y Shimizu - European Journal of Organic …, 2023 - Wiley Online Library
Carboxylic acids, amides, and esters are ubiquitous motifs in functional organic molecules.
However, the reactivities of these high oxidation state carbonyl compounds are far lower …