BACKGROUND Childhood cancer incidence and survivorship are both on the rise.
However, many lifesaving treatments threaten the prepubertal testis. Cryopreservation of …

Background The testicular organoid concept has recently been introduced in tissue
engineering to refer to testicular cell organizations modeling testicular architecture and …

The loss of germ cells and spermatogenic failure in non-obstructive azoospermia are
believed to be the main causes of male infertility. Laboratory studies have used in vitro …

Mammalian spermatogenesis is a complex developmental program that transforms mitotic
testicular germ cells (spermatogonia) into mature male gametes (sperm) for production of …

Background Spermatogenesis is one of the most complicated cellular differentiation
processes in a body. Researchers struggled to find and develop a micro‐environmental …

Spermatogenesis involves precise temporal and spatial gene expression and cell signalling
to reach a coordinated balance between self-renewal and differentiation of spermatogonial …

Worldwide, infertility affects 8-12% of couples of reproductive age and has become a
common problem. There are many ways to treat infertility, including medication, intrauterine …

In vitro spermatogenesis (IVS) using air–liquid interphase organ culture method is possible
with mouse testis tissues. The same method, however, has been hardly applicable to …

Organoids are three dimensional structures consisting of multiple cell types that recapitulate
the cellular architecture and functionality of native organs. Over the last decade, the advent …

Application of a three-dimensional (3D) culture system for in vitro proliferation and
differentiation of human spermatogonial stem cells (SSCs) is a useful tool for the …