Adrenal glucocorticoid (GC) hormones are important regulators of energy metabolism, brain
functions, and the immune system. Their release follows robust diurnal rhythms and GCs …

Glucocorticoids exert their pharmacological actions by mimicking and amplifying the function
of the endogenous glucocorticoid system's canonical physiological stress response. They …

PURPOSE Despite therapeutic advances, outcomes for patients with platinum-
resistant/refractory ovarian cancer remain poor. Selective glucocorticoid receptor modulation …

Purpose: Chemotherapy resistance remains a major problem in many solid tumors,
including breast, ovarian, and pancreatic cancer. Glucocorticoids are one potential driver of …

Objective Clinical trials with immune checkpoint inhibitors (ICI) in adrenocortical carcinoma
(ACC) have yielded contradictory results. We aimed to evaluate treatment response and …

Background: Glucocorticoids suppress inflammation. Autoimmune disease may occur after
remission of Cushing's disease (CD). However, the development of autoimmune disease in …

Probiotic consumption strongly influences local intestinal immunity and systemic immune
status. Heyndrickxia coagulans strain SANK70258 (HC) is a spore-forming lactic acid …

Adrenocortical carcinoma (ACC) is a rare cancer with high recurrence rates and
heterogeneous clinical behavior. The role of adjuvant therapy remains unclear because of …

Background Ovarian cancer has the highest mortality among gynecologic cancers, primarily
because it typically is diagnosed at a late stage and because of the development of …

Cortisol, an endogenous glucocorticoid receptor (GR) agonist, controls a broad
transcriptional program that affects T-cell activation, pro-inflammatory cytokine secretion …