Gastric pH levels were measured in samples of gastric aspirates from eight fasted beagle
dogs. The gastric pH in fasting dogs fluctuated from 2.7 to 8.3, with a mean of 6.8±0.2 (SE) …

(57) ABSTRACT A unit dosage form, such as a capsule or the like, for delivering a skeletal
muscle relaxant, such as cyclobenza prine hydrochloride, into the body in an extended or …

MATERIALS AND METHODS Materials Acetaminophen (AA) was purchased from
Yamamoto Chemical Co., Ltd.(Japan). Salicylazosulfapyridine (SASP) and sulfapyridine …

To determine the usefulness of monkey as an animal model, bioavailability and in vivo
release behaviors of theophylline (TP) after oral administration of controlled-release beads …

A matrix-in-cylinder system for sustained drug delivery, consisting of a hot-melt extruded
ethylcellulose (EC) pipe surrounding a drug containing HPMC–Gelucire® 44/14 core, was …

In order to develop a suitable beagle dog model for evaluating the bioavailability of a
sustained-release dosage form, we tried to control the gastrointestinal (GI) transit time in …

A unit dosage form, such as a capsule or the like, for delivering a skeletal muscle relaxant,
such as cyclobenzaprine hydrochloride, into the body in an extended or sustained release …

Prodrugs are chemistry-enabled drug delivery modifications of active molecules designed to
enhance their pharmacokinetic, pharmacodynamic and/or biopharmaceutical properties …

Purpose To evaluate the behaviour of an oral matrix modified release formulation in the
canine gastrointestinal tract, and establish if a mechanical weakness previously observed in …

The purpose of this study was to develop a new method using beagle dogs in order to
evaluate the colonic absorption properties of oral extended-release (ER) solid dosage …