The implantation of any foreign material into the body leads to the development of an
inflammatory and fibrotic process—the foreign body reaction (FBR). Upon implantation into a …

Neuropathic pain arises as a consequence of a lesion or disease affecting the
somatosensory system. It is generally chronic and challenging to treat. The recommended …

Studies of the peripheral nervous system rely on controlled manipulation of neuronal
function with pharmacologic and/or optogenetic techniques. Traditional hardware for these …

While depression and chronic pain are frequently comorbid, underlying neuronal circuits
and their psychopathological relevance remain poorly defined. Here we show in mice that …

Pain associates both sensory and emotional aversive components, and often leads to
anxiety and depression when it becomes chronic. Here, we characterized, in a mouse …

When cells undergo necrotic cell death in either physiological or pathophysiological settings
in vivo, they release highly immunogenic intracellular molecules and organelles into the …

Chronic pain is a maladaptive neurological disease that remains a major health problem. A
deepening of our knowledge on mechanisms that cause pain is a prerequisite to developing …

The hypothalamic neuropeptide oxytocin (OT) exerts prominent analgesic effects via central
and peripheral action. However, the precise analgesic pathways recruited by OT are largely …

The medial prefrontal cortex (mPFC) plays a major role in both sensory and affective aspects
of pain. There is extensive evidence that chronic pain produces functional changes within …

Neuropathic pain is a pathological condition induced by a lesion or disease affecting the
somatosensory system, with symptoms like allodynia and hyperalgesia. It has a multifaceted …