The Slick (Kcnt2) sodium-activated potassium (KNa) channel is a rapidly gating and weakly
voltage-dependent and sodium-dependent potassium channel with no clearly defined …

Background: Flavonoids, a group of polyphenols responsible for protective role against
many diseased conditions, provide antioxidant activity which is the reason for their medicinal …

Plasticity of inhibitory transmission in the spinal dorsal horn (SDH) is believed to be a key
mechanism responsible for pain hypersensitivity in neuropathic pain syndromes. We …

More than 450 million people worldwide suffer from diabetes, or 1 in 11 people. Chronic
hyperglycemia degrades patients' quality of life and the development of neuropathic pain …

Neuropathic pain arises as a consequence of a lesion or disease affecting the
somatosensory nervous system. It is accompanied by neuronal and non-neuronal …

Background: Peripheral neuropathic pain is a result of damage/illness of the peripheral
nerves. The mechanisms caused by its pathophysiology are not completely understood …

The adrenergic system, because of its reported implication in pain mechanisms, may be a
potential target for chronic pain treatment. We previously demonstrated that β2 …

Background Surgeries causing nerve injury can result in chronic neuropathic pain, which is
clinically managed by using antidepressant or anticonvulsant drugs. Currently, there is a …

Objectives Bupropion is an atypical antidepressant that shows robust efficacy in the
regulation of neuropathic pain. Citicoline is a dietary supplement which is used as a …

In the diagnosis of migraine, which is a neurovascular disease, gadolinium-based contrast
agents (GBCAs) are used to rule out more serious conditions. On the other hand, it remains …