Current therapies for multiple sclerosis (MS) reduce both relapses and relapse-associated
worsening of disability, which is assumed to be mainly associated with transient infiltration of …

Increasing evidence indicates the involvement of B cells in the pathogenesis of multiple
sclerosis (MS), but their precise roles are unclear. In this Review, we provide an overview of …

Multiple sclerosis (MS) is a chronic inflammatory disease of the central nervous system that
involves demyelination and axonal degeneration. Although substantial progress has been …

In the last decades, evidence suggesting the direct or indirect involvement of B cells on
multiple sclerosis (MS) pathogenesis has accumulated. The increased amount of data on …

B cells are essential components of the adaptive immune system and have important roles
in the pathogenesis of several central nervous system (CNS) diseases. Besides producing …

Multiple sclerosis is a chronic inflammatory disease of the CNS that results from the interplay
between heritable and environmental factors. Mounting evidence from different fields of …

Objective To perform a meta-analysis of randomized, blinded, multiple sclerosis (MS) clinical
trials, to test the hypothesis that efficacy of immunomodulatory disease-modifying therapies …

Background: During the past years biologic agents (also termed biologicals or biologics)
have become a crucial treatment option in immunological diseases. Numerous articles have …

Background Multiple sclerosis (MS) is a chronic and autoimmune disease of the central
nervous system (CNS), mainly characterized by inflammatory demyelination, which …

The treatment of multiple sclerosis (MS), the most common chronic inflammatory,
demyelinating and neurodegenerative disease of the central nervous system (CNS) …