Rational design of polymeric micelles for targeted therapeutic delivery

Y Zheng, Y Oz, Y Gu, N Ahamad, K Shariati… - Nano Today, 2024 - Elsevier
Polymeric micellar drug carriers have emerged as effective tools to enhance the solubility
and bioavailability of hydrophobic drugs. These micelles possess a nano size structure that …

Functionalized nanomaterials targeting NLRP3 inflammasomes driven immunomodulation: Friend or foe

R Khan - Nanoscale, 2023 - pubs.rsc.org
The advancement in drug delivery systems in recent times has significantly enhanced
therapeutic effects by enabling site-specific targeting through nanocarriers. These …

Engineering CAR-NK cell derived exosome disguised nano-bombs for enhanced HER2 positive breast cancer brain metastasis therapy

B Tao, R Du, X Zhang, B Jia, Y Gao, Y Zhao… - Journal of Controlled …, 2023 - Elsevier
HER2-positive breast cancer brain metastasis (HER2+ BCBM) is a refractory malignancy
with a high recurrence rate and poor prognosis. The efficacies of conventional treatments …

MCC950 reduces autophagy and improves cognitive function by inhibiting NLRP3-dependent neuroinflammation in a rat model of Alzheimer's disease

A Naeem, R Prakash, N Kumari, MA Khan… - Brain, Behavior, and …, 2024 - Elsevier
Alzheimer's disease (AD) is the seventh most common cause of mortality and one of the
major causes of disability and vulnerability in the elderly. AD is characterized by gradual …

Narirutin attenuates cerebral ischemia-reperfusion injury by suppressing the TXNIP/NLRP3 pathway

L Luo, S Wang, W Liu, Z Zhang, M Zhao, A Liu - Neurochemical Research, 2024 - Springer
Narirutin (Nar) is a flavonoid that is abundantly present in citrus fruits and has attracted
considerable attention because of its diverse pharmacological activities and low toxicity …

A chlorogenic acid-conjugated nanomicelle attenuates disease severity in experimental arthritis

A Vyawahare, C Jori, J Kumar, M Fareed, N Ali… - Biomaterials …, 2024 - pubs.rsc.org
Rheumatoid arthritis (RA) is a systemic immune disorder marked by synovitis, bone damage,
and cartilage erosion, leading to increased socio-economic burdens and reduced quality of …

[HTML][HTML] Recent progress of nanomedicine in the treatment of Alzheimer's disease

L Hu, Y Tao, Y Jiang, F Qin - Frontiers in Cell and Developmental …, 2023 - frontiersin.org
Alzheimer's disease (AD) is the most common cause of memory disruption in elderly
subjects, with the prevalence continuing to rise mainly because of the aging world …

[HTML][HTML] Chitosan-insulin nano-formulations as critical modulators of inflammatory cytokines and Nrf-2 pathway to accelerate burn wound healing

D Sharda, S Ghosh, P Kaur, B Basu, D Choudhury - Discover Nano, 2023 - Springer
Burn injuries are characterized by prolonged inflammatory phases, neurovascular damage,
and hypermetabolism, eventually causing improper tissue regeneration. Insulin has gained …

[HTML][HTML] Exploring exercise-driven inhibition of pyroptosis: novel insights into treating diabetes mellitus and its complications

N Li, L Zhang, X Wang, Y Zhou, L Gong - Frontiers in Endocrinology, 2023 - frontiersin.org
Diabetes mellitus (DM) and its complications are important, worldwide public health issues,
exerting detrimental effects on human health and diminishing both quality of life and …

Reactive oxygen species-responsive nanotherapy for the prevention and treatment of cerebral ischemia–reperfusion injury

J Kong, R Chu, J Wen, H Yu, J Liu, Y Sun… - Chemical Engineering …, 2024 - Elsevier
Vascular recanalization intervention is the primary recommended approach for the treatment
of ischemic stroke. However, the damage caused by cerebral ischemia-reperfusion (I/R) …