Functionalized quinolines are an important group of heterocyclic molecules with diverse,
different, and interesting biological and pharmacological activities. Traditionally, several …

Medicinal chemistry can rightfully be regarded as a cornerstone in the public health of our
modern society that combines chemistry and pharmacology with the aim of designing and …

Malaria is a tropical disease, leading to around half a million deaths annually. Antimalarials
such as quinolines are crucial to fight against malaria, but malaria control is extremely …

The emergence of resistance to first-line antimalarial drugs calls for the development of new
therapies for drug-resistant malaria. The efficacy of quinoline-based antimalarial drugs has …

The chemical behaviour of electron deficient substrate 1 was investigated with some 1, 2-bi-
nucleophilic reagents. Reaction of substrate 1 with hydrazine derivatives namely hydrazine …

Anticancer agents play a pivotal role in cancer treatment. However, most of the anticancer
drugs currently used in the clinics have a severe anticancer scenario, as well as low …

An efficient Cu-catalyzed annulation reaction of ketone oxime acetates with ortho-
trifluoroacetyl anilines has been disclosed. With the developed protocol, a series of 4 …

Acquired immune deficiency syndrome (AIDS)/human immunodeficiency virus (HIV) is one
of the largest and most devastating public health pandemics throughout the world. The …

Quinoline, isoquinoline, and indoles are common heterocyclic compounds. They have many
biological activities, such as antioxidant, anti-inflammatory, antibacterial, antitumor, anti …

Isatin–quinoline conjugates 10a–f and 11a–f were assembled by the reaction of N-
(bromobutyl) isatin derivatives 3a, b with aminoquinolines 6a–c and their corresponding …