Alzheimer's disease (AD), a progressive neurodegenerative disorder, characterized by
central cognitive dysfunction, memory loss, and intellectual decline poses a major public …

An efficient iodine-imine synergistic promoted Povarov-type multicomponent reaction was
reported for the synthesis of a practical 2, 2′-biquinoline scaffold. The tandem annulation …

Abstract Quinoline and 1, 2, 3-triazoles are well-known nitrogen-based heterocycles
presenting diverse pharmacological properties, although their antileishmanial activity is still …

In this work, three new quinolone derivatives were prepared by alkylation of 2-oxo-1, 2-
dihydroquinoline-4-carboxylic acid with ethyl 2-bromoacetate. The synthesized compounds …

The skeleton of 2-trifluoromethyl quinoline is the core structure of many natural products and
pharmaceutical molecules. The synthesis of this scaffold is limited by metal catalysis, harsh …

An efficient, solvent-free synthesis of 2-acylthieno [2, 3-b] quinolines is reported from 2-halo-
quinolinyl ketones through Cu-TEMPO catalyzed dehydrogenation, sp2-C–H …

The reactions of cis-Pt (DMSO) 2Cl2 and tropolone (HL) with 8-hydroxyquinoline (HQ) or 2-
methyl-8-hydroxyquinoline (HMQ) gave [Pt (Q)(L)](1) and [Pt (MQ)(L)](2), which present …

A novel series of 19 quinoline/1, 2, 4-triazole hybrid 6a-i and 7a-j was synthesized and
evaluated in vitro as dual COX-2/5-LOX inhibitors. Compounds 6e, 6i, and 7e displayed the …

Quinoline, a privileged scaffold in medicinal chemistry, has always been associated with a
multitude of biological activities. Especially in antimalarial and anticancer research …

Recently, glycogen synthase kinase-3β (GSK-3β) has been considered as a critical factor
implicated in Alzheimer's disease (AD). In a previous work, a 3D pharmacophore model for …