Nanoparticles promise to improve the treatment of cancer through their increasingly
sophisticated functionalisations and ability to accumulate in certain tumours. Yet recent work …

Many multicellular systems problems can only be understood by studying how cells move,
grow, divide, interact, and die. Tissue-scale dynamics emerge from systems of many …

Vascular biology is an important scientific domain that has gradually penetrated many
medical and scientific fields. Scientists are most often focused on present problems in their …

Over the past 25 years, there has been an unparalleled increase in understanding of cancer
biology. This transformation is exemplified by Hanahan and Weinberg's decision in 2011 to …

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The growth and dynamics of multicellular tissues involve tightly regulated and coordinated
morphogenetic cell behaviors, such as shape changes, movement, and division, which are …

Oxygen heterogeneity in solid tumors is recognized as a limiting factor for therapeutic
efficacy. This heterogeneity arises from the abnormal vascular structure of the tumor, but the …

Angiogenesis is the process by which blood vessels form from pre-existing vessels. It plays
a key role in many biological processes, including embryonic development and wound …

We introduce a new spatial statistic, the weighted pair correlation function (wPCF). The
wPCF extends the existing pair correlation function (PCF) and cross-PCF to describe spatial …

Purpose Tumor oxygenation is one of the key features influencing the response of cells to
radiation and chemo therapies. This study presents a novel in silico tumor model simulating …