The nuclear envelope separates the genome from the cytoplasmic environment. However,
the nuclear envelope is also physically associated with the genome and exerts influence on …

Hutchinson–Gilford progeria syndrome (HGPS) and Werner syndrome (WS) are two of the
representative genetic progeroid syndromes and have been widely studied in the field of …

Werner syndrome (WS) is a hereditary premature aging disorder characterized by visceral
fat accumulation and subcutaneous lipoatrophy, resulting in severe insulin resistance …

Werner syndrome (WS) is a progeroid syndrome caused by mutations in the WRN gene,
which encodes the RecQ type DNA helicase for the unwinding of unusual DNA structures …

Aim Whether sex differences exist in hereditary progeroid syndromes remains unclear. In
this study, we investigated sex differences in patients with Werner syndrome (WS), a model …

Background Pathogenic mutations in WRN are a cause of premature aging disease Werner
syndrome (WS). Besides accelerated aging phenotypes and cancer predisposition, patients …

Werner syndrome is an adult-onset progeria syndrome that results in various complications.
This study aimed to clarify the profile and secular variation of the disease. Fifty-one patients …

Werner syndrome is an autosomal recessive genetic disorder first described in 1904 by Otto
Werner, a German ophthalmologist. It is considered the representative progeroid syndrome …

In addition to the symptoms of aging, the main symptoms in Werner syndrome (WS), a
hereditary premature aging disease, include calcification of subcutaneous tissue with solid …

Werner syndrome is an autosomal recessive rare disease caused by a WRN gene mutation,
which is rarely reported in the Chinese population. We report the clinical and genetic data of …