Mammalian oocytes and early cleavage-stage embryos are critically dependent on their
100,000 mitochondria to develop from ovulation to compacted morula stage. They rely …

Adverse neonatal outcomes continue to be high for mothers with type 1 and type 2 diabetes,
and are far from eliminated in mothers with gestational diabetes mellitus. This is often …

Insulin resistance precedes and predicts the onset of type 2 diabetes (T2D) in susceptible
humans, underscoring its important role in the complex pathogenesis of this disease. Insulin …

Obesity, diabetes, and related metabolic disorders are major health issues worldwide. As
the epidemic of metabolic disorders continues, the associated medical co-morbidities …

The early embryo and periconceptional period is a window during which environmental
factors may cause permanent change in the pattern and characteristics of development …

Age-related macular degeneration (AMD) is a major cause of severe vision loss in elderly
people. Diabetes mellitus is a common endocrine disorder with serious consequences, and …

The prevalence of obesity in adults worldwide, and specifically in women of reproductive
age, is concerning given the risks to fertility posed by the increased risk of type 2 diabetes …

The results of different human epidemiological datasets provided the impetus to introduce
the now commonly accepted theory coined as 'developmental programming', whereby the …

Overweight, obesity, and their comorbidities remain global health challenges. When
established early in life, overweight is often sustained into adulthood and contributes to the …

Purpose To assess the effect of body mass index (BMI) on morphokinetic parameters of
human embryos evaluated with time-lapse technology during in vitro culture. Methods A …