The efficacy of islet transplantation is limited by poor graft vascularization. We herein
demonstrated that microvesicles (MVs) released from endothelial progenitor cells (EPCs) …

Within the pancreatic islet, the β-cell represents the ultimate biosensor. Its central function is
to accurately sense glucose levels in the blood and consequently release appropriate …

Although pancreatic islets comprise only 1–2% of pancreatic mass, they receive 5–10% of
pancreatic blood flow. Blood vessels within pancreatic islets are of a greater density than …

Aims/hypothesis Beta cell replacement is a potential cure for type 1 diabetes. In humans,
islet transplants are currently infused into the liver via the portal vein, although this site has …

Low oxygenation of islets contributes to cellular death and dysfunction during preparation of
islets for transplantation, as well as posttransplantation. Interventions at these different steps …

Pancreatic islet transplantation is a therapeutic option to replace destroyed β cells in
autoimmune diabetes. Islets are transplanted into the liver via the portal vein; however …

Bone marrow-derived early endothelial progenitor cells (BM-EPCs) are a clinical tool for
enhancing revascularization. However, the therapeutic efficacy of co-transplantation of BM …

Aims/hypothesis Recent studies suggest that donor endothelial cells may contribute to islet
graft revascularisation. Since islet endothelial cells disappear during culture, we …

Background. Insufficient revascularization of transplanted islets may result in chronic
hypoxia and loss of islet function. This study investigated whether simple culture of islets …

OBJECTIVE—Insufficient development of a new intra-islet capillary network after
transplantation may be one contributing factor to the failure of islet grafts in clinical …