Over the last 20 years it has become clear that colorectal cancer (CRC) evolves through
multiple pathways. These pathways may be defined on the basis of two molecular …

Background Microsatellite instability (MSI) causes hereditary non-polyposis colorectal
cancer (HNPCC), and occurs in about 15 per cent of sporadic colorectal cancers. Although …

ASCO 2006 Update of Recommendations for the Use of Tumor Markers in Gastrointestinal
Cancer Page 1 ASCO 2006 Update of Recommendations for the Use of Tumor Markers in …

Microsatellite instability (MSI) is a clonal change in the number of repeated DNA nucleotide
units in microsatellites. It arises in tumors with deficient mismatch repair due to the …

Microsatellite instability (MSI) analysis of colorectal cancers is clinically useful to identify
patients with hereditary nonpolyposis colorectal cancer (HNPCC) caused by germline …

Objective: The relationship between microsatellite instability (MSI) and response to
neoadjuvant chemoradiation in rectal cancer is not well understood. Background: We …

An active stroma is important for cancer cell invasion and metastasis. We investigated the
expression of fibroblast activation protein (FAP) in relation to patient prognosis in colorectal …

Background Mutations in KRAS, BRAF, PIK3CA and PTEN expression have been in focus to
predict the effect of epidermal growth factor receptor-blocking therapy in colorectal cancer …

Background Colorectal tumors caused by failure of the DNA mismatch repair system
commonly show microsatellite instability. Our goals were to compare the performance of two …

Microsatellite instability (MSI) is a hallmark of mismatch repair (MMR) deficiency. High levels
of MSI at mononucleotide and dinucleotide repeats in colorectal cancer (CRC) are attributed …