Purpose Cathepsin and plasmin may favor cancer cell invasion degrading extracellular
matrix. Plasmin formation from plasminogen is regulated by plasminogen activator inhibitor …

Purpose: Colorectal cancers with microsatellite instability–high (MSI-H) status, due to
mismatch repair deficiency, are associated with poor patient outcomes after relapse. We …

Colorectal cancer (CRC) is one of the most frequent cancers in the Western world and
represents a major health burden. CRC development is a multi-step process that spans 10 …

The MSH3 gene is one of the DNA mismatch repair (MMR) genes that has undergone
somatic mutation frequently in MMR-deficient cancers. MSH3, together with MSH2, forms the …

Background Microsatellite instability (MSI) is a prognostic marker in colorectal cancer (CRC).
The biological significance of MSI‐low (MSI‐L) phenotype and its differences with …

Microsatellite alterations within genomic DNA frameshift as a result of defective DNA
mismatch repair (MMR). About 15% of sporadic colorectal cancers (CRCs) manifest …

The classification of colorectal cancer (CRC) by microsatellite instability (MSI) status is
important for effective clinical management. In fact, microsatellite instability-high (MSI-H) …

The influence of microsatellite instability (MSI) on the prognosis of colorectal cancer (CRC)
requires more investigation. We assessed the role of MSI status in survival of individuals …

Colorectal cancer is the most prevalent among digestive system cancers. Carcinogenesis
relies on disrupted control of cellular processes, such as metabolism, proliferation, DNA …

The clinical management of cancers has progressed rapidly into the immunopathology era,
with the unprecedented histology-agnostic approval of pembrolizumab in mismatch repair …