Colorectal cancer (CRC) is the third most prevalent cancer, with approximately one million
cases estimated world wide in 2006, resulting in more than 500,000 deaths. Approximately …

The detection of microsatellite-unstable (microsatellite instability [MSI]) colorectal
carcinomas (CRCs) has prognostic value and can help screen for Lynch syndrome. We …

Colorectal carcinogenesis relies on loss of homeostasic mechanisms regulating cell
proliferation, differentiation and survival. These cell processes have been reported to be …

Microsatellite DNA sequences display allele length alterations or microsatellite instability
(MSI) in tumor tissues, and MSI is used diagnostically for tumor detection and classification …

Context.—Criteria for microsatellite instability (MSI) testing to rule out hereditary
nonpolyposis colorectal cancer were recently revised and include parameters such as age …

Introduction Despite a well-known prognostic role in colorectal cancer, the genomic profiling
of tumour budding remains to be elucidated. We aim to review the association of common …

Microsatellite instability (MSI) testing is useful for identifying patients with hereditary
nonpolyposis colorectal cancer and detecting sporadic colorectal cancer that develops …

Microsatellite instability (MSI) is the molecular hallmark of DNA mismatch repair deficiency.
Since its initial description in colorectal cancer (CRC) in 1993 and its association with Lynch …

BACKGROUND: Appropriate stratification tools for targeted surveillance after resection for
colorectal cancer (CRC) are lacking. The objective of the current study was to investigate the …

Although microsatellite instability-high (MSI-H) colorectal cancers (CRCs) have been shown
to exhibit a distinct phenotype, the clinical value of MSI-low (MSI-L) in CRC remains unclear …