The immune-inflammatory response is associated with increased nitro-oxidative stress. The
aim of this mechanistic review is to examine:(a) the role of redox-sensitive transcription …

Over the last two decades, our understanding of the pathological role of hepatic stellate cells
(HSCs) in fibrotic liver disease has increased dramatically. As HSCs are identified as the …

Regulators of G protein signaling (RGS) proteins modulate the physiologic actions of many
neurotransmitters, hormones, and other signaling molecules. Human RGS proteins …

Background Potential routes whereby systemic inflammation, oxidative stress and
mitochondrial dysfunction may drive the development of endothelial dysfunction and …

Hostile microenvironment produced by abnormal blood vessels, which is characterized by
hypoxia, low pH value and increasing interstitial fluid pressure, would facilitate tumor …

G protein-coupled receptor signaling mechanisms are implicated in many aspects of
cardiovascular control, and dysfunction of such signaling mechanisms is commonly …

Adaptive biological mechanisms to hypoxia are crucial to maintain oxygen homeostasis,
especially in the brain. Pericytes, cells uniquely positioned at the blood-brain interface …

Current therapies for pregnancy-related hypertension and its complications remain
inadequate, although an increasing role for maternal susceptibility is becoming evident …

G protein‐coupled receptors (GPCRs) are the most prominent receptors on the surface of
the cell and play a central role in the regulation of cardiac and metabolic functions. GPCRs …

Single-cell RNA sequencing (scRNA-seq) has enabled the identification of novel gene
signatures and cell heterogeneity in numerous tissues and diseases. Here we review the …