Mechanisms and models in heart failure: the biomechanical model and beyond

DL Mann, MR Bristow - Circulation, 2005 - Am Heart Assoc
resultant striking increase in morbidity and mortality. The transition to symptomatic heart
failure is accompanied by further activation of neurohormonal and cytokine systems, as well …

Unchain my heart: the scientific foundations of cardiac repair

S Dimmeler, AM Zeiher… - The Journal of clinical …, 2005 - Am Soc Clin Investig
In humans, the biological limitations to cardiac regenerative growth create both a clinical
imperative—to offset cell death in acute ischemic injury and chronic heart failure—and a …

A phase I clinical trial of the treatment of Crohn's fistula by adipose mesenchymal stem cell transplantation

D García-Olmo, M García-Arranz, D Herreros… - Diseases of the colon & …, 2005 - Springer
PURPOSE The effective management of fistulas in patients with Crohn's disease presents
an extremely challenging problem. Mesenchymal adult stem cells extracted from certain …

Bone marrow–derived hematopoietic cells generate cardiomyocytes at a low frequency through cell fusion, but not transdifferentiation

JM Nygren, S Jovinge, M Breitbach, P Säwén, W Röll… - Nature medicine, 2004 - nature.com
Recent studies have suggested that bone marrow cells might possess a much broader
differentiation potential than previously appreciated. In most cases, the reported efficiency of …

Experimental and clinical regenerative capability of human bone marrow cells after myocardial infarction

F Fernández-Avilés, JA San Román… - Circulation …, 2004 - Am Heart Assoc
Bone marrow mononuclear cells (BMCs) from 20 patients with extensive reperfused
myocardial infarction (MI) were used to assess their myocardial regenerative capability “in …

Leukocytosis and ischemic vascular disease morbidity and mortality: is it time to intervene?

BS Coller - Arteriosclerosis, thrombosis, and vascular biology, 2005 - Am Heart Assoc
The association between leukocytosis and increased morbidity and mortality of ischemic
vascular disease has been observed for more than half a century, and recent studies in> …

CD14+CD34low Cells With Stem Cell Phenotypic and Functional Features Are the Major Source of Circulating Endothelial Progenitors

P Romagnani, F Annunziato, F Liotta, E Lazzeri… - Circulation …, 2005 - Am Heart Assoc
Endothelial progenitor cells (EPCs) seem to be a promising tool for cell therapy of acute
myocardial infarction, but their nature is still unclear. We show here that EPCs obtainable …

[HTML][HTML] Endothelial progenitor cells in atherosclerosis

F Du, J Zhou, R Gong, X Huang… - … in bioscience: a …, 2012 - ncbi.nlm.nih.gov
Endothelial progenitor cells (EPCs) are involved in the maintenance of endothelial
homoeostasis and in the process of new vessel formation. Experimental and clinical studies …

Bone marrow stem cell transplantation for cardiac repair

HK Haider, M Ashraf - American Journal of Physiology …, 2005 - journals.physiology.org
Cardiomyocytes respond to physiological or pathological stress only by hypertrophy and not
by an increase in the number of functioning cardiomyocytes. However, recent evidence …

Granulocyte Colony-Stimulating Factor–Mobilized Circulating c-Kit+/Flk-1+ Progenitor Cells Regenerate Endothelium and Inhibit Neointimal Hyperplasia After …

M Takamiya, M Okigaki, D Jin, S Takai… - … , and vascular biology, 2006 - Am Heart Assoc
Background—Granulocyte colony-stimulating factor (G-CSF) treatment was shown to inhibit
neointimal formation of balloon-injured vessels, whereas neither the identification of …