Synthetic molecular probes, chemosensors, and nanosensors used in combination with
innovative assay protocols hold great potential for the development of robust, low-cost, and …

The mucus clearance system is the dominant mechanical host defense system of the human
lung. Mucus is cleared from the lung by cilia and airflow, including both two-phase gas-liquid …

In human pathophysiology, the clash between microbial infection and host immunity
contributes to multiple diseases. Cystic fibrosis (CF) is a classical example of this …

Neutrophil migration and its role during inflammation has been the focus of increased
interest in the past decade. Advances in live imaging and the use of new model systems …

In this review article we examine the role of glutathione reductase in the regulation,
modulation and maintenance of cellular redox homoeostasis. Glutathione reductase is …

Endogenous bioactive lipids are part of a complex network that modulates a plethora of
cellular and molecular processes involved in health and disease, of which inflammation …

As the focus of implantable biomaterials has shifted from bioinert implants to bioactive
designs, recent research has highlighted the complex interactions between cell physiologic …

Standard follow-up and symptomatic treatment have allowed most patients with cystic
fibrosis to live to young adulthood. However, many patients still die prematurely from …

Background Inflammation in the lung is the body's natural response to injury. It acts to
remove harmful stimuli such as pathogens, irritants, and damaged cells and initiate the …

In cystic fibrosis (CF) airways, Pseudomonas aeruginosa forms cellular aggregates called
biofilms that are thought to contribute to chronic infection. To form aggregates, P. aeruginosa …