The aim of this review is to provide a systematic overview on constitutively active G-protein-
coupled receptors (GPCRs), a rapidly evolving area in signal transduction research. We will …

Baculovirus has emerged as a novel vector for in vivo and in vitro gene delivery. In addition,
the applications of baculovirus-mediated gene transfer have been explosively expanded to …

Although recombinant baculovirus vectors can be an efficient tool for gene transfer into
mammalian cells in vitro, gene transduction in vivo has been hampered by the inactivation of …

Baculoviruses are enveloped, insect-specific viruses with large double-stranded DNA
genomes. Among all the baculovirus species, Autographa californica multiple …

To characterize the induction of antigen-specific immune response mediated by baculovirus,
vectors expressing the E2 glycoprotein of hepatitis C virus or the carcinoembryonic antigen …

The baculovirus Autographa californica multiple nucleopolyhedrovirus (AcMNPV) can infect
a variety of mammalian cells, as well as insect cells, facilitating its use as a viral vector for …

Despite significant advances over the past decades of research, pancreatic cancer (PC)
continues to have the worst 5-year survival of any malignancy. Dendritic cells (DCs) are the …

Safety and reliability of transgene integration in human genome continue to pose challenges
for stem cell-based gene therapy. Here, we report a baculovirus-transcription activator-like …

Many different types of therapeutic genes, ranging from suicide genes, tumor suppressor
genes, to genes encoding tumor-specific antigens, have been successfully delivered by …

Significant progress in the application of baculoviral vectors for gene delivery into
mammalian cells calls for the development of powerful methods for virus purification and …