Network science of biological systems at different scales: A review

M Gosak, R Markovič, J Dolenšek, MS Rupnik… - Physics of life …, 2018 - Elsevier
Network science is today established as a backbone for description of structure and function
of various physical, chemical, biological, technological, and social systems. Here we review …

Big data in IBD: big progress for clinical practice

NSS Tabib, M Madgwick, P Sudhakar, B Verstockt… - Gut, 2020 - gut.bmj.com
IBD is a complex multifactorial inflammatory disease of the gut driven by extrinsic and
intrinsic factors, including host genetics, the immune system, environmental factors and the …

CD44/CD44v6 a reliable companion in cancer-initiating cell maintenance and tumor progression

Z Wang, K Zhao, T Hackert, M Zöller - Frontiers in cell and …, 2018 - frontiersin.org
Metastasis is the leading cause of cancer death, tumor progression proceeding through
emigration from the primary tumor, gaining access to the circulation, leaving the circulation …

TNF-alpha and metalloproteases as key players in melanoma cells aggressiveness

S Rossi, M Cordella, C Tabolacci, G Nassa… - Journal of Experimental …, 2018 - Springer
Background Melanoma aggressiveness determines its growth and metastatic potential. This
study aimed at identifying new molecular pathways controlling melanoma cell malignancy …

Research hotspot and trend analysis in the diagnosis of inflammatory bowel disease: a machine learning bibliometric analysis from 2012 to 2021

C Liu, R Yu, J Zhang, S Wei, F Xue, Y Guo… - Frontiers in …, 2022 - frontiersin.org
Aims This study aimed to conduct a bibliometric analysis of the relevant literature on the
diagnosis of inflammatory bowel disease (IBD), and show its current status, hot spots, and …

Inflammatory bowel disease biomarkers of human gut microbiota selected via different feature selection methods

B Bakir-Gungor, H Hacılar, A Jabeer, OU Nalbantoglu… - PeerJ, 2022 - peerj.com
The tremendous boost in next generation sequencing and in the “omics” technologies
makes it possible to characterize the human gut microbiome—the collective genomes of the …

From isles of Königsberg to islets of Langerhans: examining the function of the endocrine pancreas through network science

A Stožer, M Šterk, E Paradiž Leitgeb… - Frontiers in …, 2022 - frontiersin.org
Islets of Langerhans are multicellular microorgans located in the pancreas that play a central
role in whole-body energy homeostasis. Through secretion of insulin and other hormones …

Network pharmacology of adaptogens in the assessment of their pleiotropic therapeutic activity

A Panossian, T Efferth - Pharmaceuticals, 2022 - mdpi.com
The reductionist concept, based on the ligand–receptor interaction, is not a suitable model
for adaptogens, and herbal preparations affect multiple physiological functions, revealing …

Whither systems medicine?

R Apweiler, T Beissbarth, MR Berthold… - … & molecular medicine, 2018 - nature.com
New technologies to generate, store and retrieve medical and research data are inducing a
rapid change in clinical and translational research and health care. Systems medicine is the …

The scope of big data in one medicine: unprecedented opportunities and challenges

ME McCue, AM McCoy - Frontiers in veterinary science, 2017 - frontiersin.org
Advances in high-throughput molecular biology and electronic health records (EHR),
coupled with increasing computer capabilities have resulted in an increased interest in the …