Mechanistic insight into oxidative stress-triggered signaling pathways and type 2 diabetes

A Singh, R Kukreti, L Saso, S Kukreti - Molecules, 2022 - mdpi.com
Oxidative stress (OS) is a metabolic dysfunction mediated by the imbalance between the
biochemical processes leading to elevated production of reactive oxygen species (ROS) …

Reactive oxygen species (ROS)-based nanomedicine

B Yang, Y Chen, J Shi - Chemical reviews, 2019 - ACS Publications
Reactive oxygen species (ROS) play an essential role in regulating various physiological
functions of living organisms. The intrinsic biochemical properties of ROS, which underlie …

Mitochondrial ROS promotes susceptibility to infection via gasdermin D-mediated necroptosis

CG Weindel, EL Martinez, X Zhao, CJ Mabry, SL Bell… - Cell, 2022 - cell.com
Although mutations in mitochondrial-associated genes are linked to inflammation and
susceptibility to infection, their mechanistic contributions to immune outcomes remain ill …

Cell death in photodynamic therapy: From oxidative stress to anti-tumor immunity

C Donohoe, MO Senge, LG Arnaut… - … et Biophysica Acta (BBA …, 2019 - Elsevier
Photodynamic therapy is a promising approach for cancer treatment that relies on the
administration of a photosensitizer followed by tumor illumination. The generated oxidative …

Role of Nrf2/HO-1 system in development, oxidative stress response and diseases: an evolutionarily conserved mechanism

A Loboda, M Damulewicz, E Pyza, A Jozkowicz… - Cellular and molecular …, 2016 - Springer
The multifunctional regulator nuclear factor erythroid 2-related factor (Nrf2) is considered not
only as a cytoprotective factor regulating the expression of genes coding for anti-oxidant …

[HTML][HTML] Is melatonin the cornucopia of the 21st century?

N Ferlazzo, G Andolina, A Cannata, MG Costanzo… - Antioxidants, 2020 - mdpi.com
Melatonin, an indoleamine hormone produced and secreted at night by pinealocytes and
extra-pineal cells, plays an important role in timing circadian rhythms (24-h internal clock) …

A pharmacological update of ellagic acid

JL Ríos, RM Giner, M Marín, MC Recio - Planta medica, 2018 - thieme-connect.com
Ellagic acid is a common metabolite present in many medicinal plants and vegetables. It is
present either in free form or as part of more complex molecules (ellagitannins), which can …

Modulation of oxidative stress as an anticancer strategy

C Gorrini, IS Harris, TW Mak - Nature reviews Drug discovery, 2013 - nature.com
The regulation of oxidative stress is an important factor in both tumour development and
responses to anticancer therapies. Many signalling pathways that are linked to …

Antioxidants and human diseases

P Rajendran, N Nandakumar, T Rengarajan… - Clinica chimica acta, 2014 - Elsevier
Oxidative stress plays a pivotal role in the development of human diseases. Reactive
oxygen species (ROS) that includes hydrogen peroxide, hyphochlorus acid, superoxide …

Mammalian heat shock response and mechanisms underlying its genome-wide transcriptional regulation

DB Mahat, HH Salamanca, FM Duarte, CG Danko… - Molecular cell, 2016 - cell.com
The heat shock response (HSR) is critical for survival of all organisms. However, its scope,
extent, and the molecular mechanism of regulation are poorly understood. Here we show …