Overview IL-7 is a member of the family of cytokines with four anti-parallel α helixes that bind
Type I cytokine receptors. It is produced by stromal cells and is required for development …

Interleukin-7 (IL-7) was initially isolated more than 10 years ago. 1-4 Nevertheless, the
complete set of physiologic roles for this cytokine, especially those involving lymphocyte …

Immune checkpoint blockade (ICB) therapy potently revives T cell's response to cancer.
However, patients suffered with tumors that had inadequate infiltrated immune cells only …

Interleukin-7 (IL-7) is a cytokine that has been known since long in immunology, mainly
regarding its effects on T-cells and B-cells. IL-7 has been demonstrated to be necessary for …

To investigate the role of interleukin 7 (IL-7) in the development of the lymphoid system, we
have generated two lines of transgenic mice carrying an IL-7 cDNA fused to an …

Immunodeficiency due to inborn errors, infections, autoimmune diseases and the toxicity of
certain therapies, has become an important clinical challenge. Strategies to enhance …

Cancer immunotherapy has revolutionized the treatment of advanced cancers and is quickly
becoming an option for early‐stage disease. By reactivating the host immune system …

Impaired immune reconstitution has moved to the forefront of clinical problems limiting
progress in allogeneic bone marrow transplantation (BMT). The identification of therapies …

The effect of age and sex on the predictive value of colorectal cancer (CRC) patients treated
with immune checkpoint inhibitors (ICIs) has been controversial, and the effect of specific …

To optimize polynucleotide vaccinations for protective antitumor immunity we used a self-
replicating RNA vaccine in which Semliki Forest virus replicase drives RNA expression of …