Large vessel occlusions (LVOs), variably defined as blockages of the proximal intracranial
anterior and posterior circulation, account for approximately 24% to 46% of acute ischemic …

Conventional angiographic evaluation has advantages, including its reliable demonstration
of occlusion versus subtotal occlusion, well standardized recanalization grading, and high …

Background Despite successful recanalization after endovascular treatment, many patients
with acute ischemic stroke due to large vessel occlusion still show functional dependence …

Background Thrombo-inflammation is an important checkpoint that orchestrates infarct
development in ischemic stroke. However, the underlying mechanism remains largely …

Background and Purpose—Endovascular therapy is increasingly used in acute ischemic
stroke treatment and is now considered the gold standard approach for selected patient …

Background Mechanical thrombectomy with stent-retrievers results in higher recanalization
rates compared with previous devices. Despite successful recanalization rates …

ESCAPE is a prospective, multicenter, randomized clinical trial that will enroll subjects with
the following main inclusion criteria: less than 12 h from symptom onset, age> 18, baseline …

Tissue plasminogen activator (tPA) is the only therapeutic agent approved to treat patients
with acute ischemic stroke. The clinical benefits of tPA manifest when the agent is …

Endovascular therapy with mechanical thrombectomy is a formidable treatment for severe
acute ischemic stroke caused by occlusion of a proximal intracranial artery. Its strong …

Background and Purpose: Acute ischemic stroke (AIS) is a serious threat to the life and
health of middle-aged and elderly people. Mechanical thrombectomy offers the advantages …