The transferrin receptor (TfR) is a cell membrane-associated glycoprotein involved in the
cellular uptake of iron and in the regulation of cell growth. Iron uptake occurs via the …

Summary Immunoglobulin G4 (IgG4) antibodies have been known for some time to be
functionally monovalent. Recently, the structural basis for this monovalency has been …

Human antibody 2G12 neutralizes a broad range of human immunodeficiency virus type 1
(HIV-1) isolates by binding an unusually dense cluster of carbohydrate moieties on the …

Unlike other immunoglobulin G (IgG) subclasses, IgG4 antibodies in plasma have been
reported to be functionally monovalent. In this paper we show that the apparent …

Various native and hinge-modified forms of Ig with identical Ids were reacted with an anti-Id
mAb, and the resultant immune complexes were analyzed by negative stain immunoelectron …

Immunoglobulins are biomolecules involved in defence against foreign substances.
Flexibility is key to their functional properties in relation to antigen binding and receptor …

MAB007, an IgG1 monoclonal antibody, is unique because of the presence of a free
cysteine residue in the Fab region at position 104 on the heavy chain in the CDR3 region …

Background: Antibody–cytokine fusion proteins consist of cytokines fused to an antibody to
improve antibody-targeted cancer immunotherapy. These molecules have the capacity to …

Anti-HER2/neu therapy of human HER2/neu-expressing malignancies such as breast
cancer has shown only partial success in clinical trials. To expand the clinical potential of …

The human IgG1 antibody subclass shows distinct properties compared with the IgG2, IgG3,
and IgG4 subclasses and is the most exploited subclass in therapeutic antibodies. It is the …