Pokeweed antiviral protein, a ribosome inactivating protein: activity, inhibition and prospects
AV Domashevskiy, DJ Goss - Toxins, 2015 - mdpi.com
Viruses employ an array of elaborate strategies to overcome plant defense mechanisms and
must adapt to the requirements of the host translational systems. Pokeweed antiviral protein …
must adapt to the requirements of the host translational systems. Pokeweed antiviral protein …
Scaffolds to promote spinal cord regeneration
S Sakiyama-Elbert, PJ Johnson, SI Hodgetts… - Handbook of clinical …, 2012 - Elsevier
Substantial research effort in the spinal cord injury (SCI) field is directed towards reduction of
secondary injury changes and enhancement of tissue sparing. However, pathway repair …
secondary injury changes and enhancement of tissue sparing. However, pathway repair …
Facilitation of neuropathic pain by the NPY Y1 receptor-expressing subpopulation of excitatory interneurons in the dorsal horn
Endogenous neuropeptide Y (NPY) exerts long-lasting spinal inhibitory control of
neuropathic pain, but its mechanism of action is complicated by the expression of its …
neuropathic pain, but its mechanism of action is complicated by the expression of its …
Anti-nociceptive effects of selectively destroying substance P receptor-expressing dorsal horn neurons using [Sar9, Met (O2) 11]-substance P-saporin: behavioral and …
RG Wiley, RH Kline IV, CJ Vierck Jr - Neuroscience, 2007 - Elsevier
Lumbar intrathecal injections of substance P-saporin (SP-sap) destroy dorsal horn neurons
that express the neurokinin-1 receptor (NK-1R) resulting in decreased responses to a range …
that express the neurokinin-1 receptor (NK-1R) resulting in decreased responses to a range …
Loss of neurons in rostral ventromedial medulla that express neurokinin-1 receptors decreases the development of hyperalgesia
SG Khasabov, DA Simone - Neuroscience, 2013 - Elsevier
It is well known that neurons in the rostral ventromedial medulla (RVM) are involved in
descending modulation of nociceptive transmission in the spinal cord. It has been shown …
descending modulation of nociceptive transmission in the spinal cord. It has been shown …
A role for neurokinin-1 receptor neurons in the rostral ventromedial medulla in the development of chronic postthoracotomy pain
SG Khasabov, JCF Wang, DA Simone, GR Strichartz - Pain, 2017 - journals.lww.com
Thoracotomy results in chronic postoperative pain (CPTP) in half of the cases. Earlier
findings in rat models of persistent postsurgical pain suggest that spinal pathways are critical …
findings in rat models of persistent postsurgical pain suggest that spinal pathways are critical …
PDZ Domain in the Engineering and Production of a Saporin Chimeric Toxin as a Tool for targeting Cancer Cells
F Giansanti, D Sabatini, MR Pennacchio… - Journal of Cellular …, 2015 - Wiley Online Library
In this paper we have studied a PDZ protein domain as a possible tool for cellular targeting
of the ribosome inactivating protein Saporin, exploiting the ability of PDZ domains to …
of the ribosome inactivating protein Saporin, exploiting the ability of PDZ domains to …
Engineering a switchable toxin: the potential use of PDZ domains in the expression, targeting and activation of modified saporin variants
F Giansanti, L Di Leandro, I Koutris… - … , Design & Selection, 2010 - academic.oup.com
A critical problem in studying ribosome-inactivating proteins (RIPs) lies in the very limited
possibility to produce them in heterologous systems. In fact, their inherent toxicity for the …
possibility to produce them in heterologous systems. In fact, their inherent toxicity for the …
Ribosome-inactivating protein-containing conjugates for therapeutic use
G Fracasso, F Stirpe, M Colombatti - Toxic plant proteins, 2010 - Springer
A number of plant proteins inhibit protein synthesis by irreversibly inactivating the 60S
ribosomal subunit in a catalytical, that is, enzymatic, manner. For this property, they are …
ribosomal subunit in a catalytical, that is, enzymatic, manner. For this property, they are …
Expression and purification of cysteine introduced recombinant saporin
E Günhan, M Swe, M Palazoglu, JC Voss… - Protein expression and …, 2008 - Elsevier
Saporin, a ribosome inactivating protein is widely used for immunotoxin construction. Here
we describe a mutation of saporin (sap)-3 DNA by introducing a cysteine residue, followed …
we describe a mutation of saporin (sap)-3 DNA by introducing a cysteine residue, followed …