Viruses employ an array of elaborate strategies to overcome plant defense mechanisms and
must adapt to the requirements of the host translational systems. Pokeweed antiviral protein …

Substantial research effort in the spinal cord injury (SCI) field is directed towards reduction of
secondary injury changes and enhancement of tissue sparing. However, pathway repair …

Endogenous neuropeptide Y (NPY) exerts long-lasting spinal inhibitory control of
neuropathic pain, but its mechanism of action is complicated by the expression of its …

Lumbar intrathecal injections of substance P-saporin (SP-sap) destroy dorsal horn neurons
that express the neurokinin-1 receptor (NK-1R) resulting in decreased responses to a range …

It is well known that neurons in the rostral ventromedial medulla (RVM) are involved in
descending modulation of nociceptive transmission in the spinal cord. It has been shown …

Thoracotomy results in chronic postoperative pain (CPTP) in half of the cases. Earlier
findings in rat models of persistent postsurgical pain suggest that spinal pathways are critical …

In this paper we have studied a PDZ protein domain as a possible tool for cellular targeting
of the ribosome inactivating protein Saporin, exploiting the ability of PDZ domains to …

A critical problem in studying ribosome-inactivating proteins (RIPs) lies in the very limited
possibility to produce them in heterologous systems. In fact, their inherent toxicity for the …

A number of plant proteins inhibit protein synthesis by irreversibly inactivating the 60S
ribosomal subunit in a catalytical, that is, enzymatic, manner. For this property, they are …

Saporin, a ribosome inactivating protein is widely used for immunotoxin construction. Here
we describe a mutation of saporin (sap)-3 DNA by introducing a cysteine residue, followed …