Chemokines produced in the liver during hepatitis C virus (HCV) infection induce migration
of activated T cells from the periphery to infected parenchyma. The milieu of chemokines …

Heart failure has become an increasingly prevalent disorder with considerable morbidity
and mortality. While many causal mechanisms such as inherited cardiomyopathies …

Chronic chagasic cardiomyopathy is a leading cause of heart failure in Latin American
countries. About 30% of Trypanosoma cruzi–infected individuals develop this severe …

Compounds targeting the chemokine receptor CCR5 have recently been approved for
treatment of human immunodeficiency virus (HIV) infection. Given the central role of CCR5 …

In the age of genomics, public understanding of complex scientific knowledge is critical. To
combat reductionistic views, it is necessary to generate and organize educational material …

Toll-like receptor 9 (TLR9) is a member of the innate immune system and has been shown to
influence myocardial function, but its role in myocarditis is hitherto unknown. We therefore …

Previously, we have shown that CCR5 transcription is regulated by CREB‐1. However, the
ubiquitous pattern of CREB‐1 expression suggests the involvement of an additional level of …

Purpose This study was carried out to investigate the effects of a triptolide (TP)
nanosuspension and methotrexate (MTX) nanosuspension on left ventricular remodeling …

Since the recognition of human acquired immune deficiency syndrome, numerous classes of
pharmacologic therapeutics have been developed to manage the disease. Current therapy …

Background Herpesviruses have evolved chemokines and chemokine receptors, which
modulate the recruitment of human leukocytes during the inflammatory response to infection …