All components of the CNS are surrounded by a diffuse extracellular matrix (ECM)
containing chondroitin sulphate proteoglycans (CSPGs), heparan sulphate proteoglycans …

Severe spinal cord injury causes permanent loss of function and sensation throughout the
body. The trauma causes a multifaceted torrent of pathophysiological processes which …

Memory, defined as the storage and use of learned information in the brain, is necessary to
modulate behavior and critical for animals to adapt to their environments and survive …

Perineuronal nets (PNNs) are specialized extracellular matrix structures that surround
specific neurons in the brain and spinal cord, appear during critical periods of development …

Perineuronal nets (PNNs) are chondroitin-sulfate glycosaminoglycan (CS-GAG) containing
extracellular matrix structures that assemble around neurons involved in learning, memory …

As chemically specialized forms of the extracellular matrix in the central nervous system,
polyanionic perineuronal nets (PNs) contain diverse constituents including chondroitin …

Emerging research on neuroplasticity processes in psychosis spectrum illnesses—from the
synaptic to the macrocircuit levels—fill key gaps in our models of pathophysiology and open …

Plasticity, and in particular, neurogenesis, is a promising target to treat and prevent a wide
variety of diseases (eg, epilepsy, stroke, dementia). There are different types of plasticity …

Degeneration of neurons and circuits across the striatum shows stereotyped time-course
and spatial topography patterns that are distinct for Huntington's disease, Parkinson's …

Overindulgence, excessive consumption, and a pattern of compulsive use of natural
rewards, such as certain foods or drugs of abuse, may result in the development of obesity …