[HTML][HTML] Osteoarthritis: pathogenic signaling pathways and therapeutic targets

Q Yao, X Wu, C Tao, W Gong, M Chen, M Qu… - Signal transduction and …, 2023 - nature.com
Osteoarthritis (OA) is a chronic degenerative joint disorder that leads to disability and affects
more than 500 million population worldwide. OA was believed to be caused by the wearing …

The burden of osteoarthritis: Is it a rising problem?

WJ Scheuing, AM Reginato, M Deeb… - Best Practice & Research …, 2023 - Elsevier
The objective of this review is to provide an overview of the current status of osteoarthritis
(OA) as one of the most common joint disorders worldwide. Despite being the 11th cause of …

[HTML][HTML] The prevalence of hip osteoarthritis: a systematic review and meta-analysis

Z Fan, L Yan, H Liu, X Li, K Fan, Q Liu, JJ Li… - Arthritis Research & …, 2023 - Springer
Objective To estimate the global prevalence of hip osteoarthritis (HOA) through a systematic
review and meta-analysis, and to determine by regression analysis the respective …

[HTML][HTML] Angiopoietin-like 3-derivative LNA043 for cartilage regeneration in osteoarthritis: a randomized phase 1 trial

N Gerwin, C Scotti, C Halleux, M Fornaro, J Elliott… - Nature Medicine, 2022 - nature.com
Osteoarthritis (OA) is a common, debilitating, chronic disease with no disease-modifying
drug approved to date. We discovered LNA043—a derivative of angiopoietin-like 3 …

[HTML][HTML] Boosting cartilage repair with silk fibroin-DNA hydrogel-based cartilage organoid precursor

C Shen, J Wang, G Li, S Hao, Y Wu, P Song, Y Han… - Bioactive materials, 2024 - Elsevier
Osteoarthritis (OA), a common degenerative disease, is characterized by high disability and
imposes substantial economic impacts on individuals and society. Current clinical …

[HTML][HTML] Biomechanics of chondrocytes and chondrons in healthy conditions and osteoarthritis: a review of the mechanical characterisations at the microscale

S Pettenuzzo, A Arduino, E Belluzzi, A Pozzuoli… - Biomedicines, 2023 - mdpi.com
Biomechanical studies are expanding across a variety of fields, from biomedicine to
biomedical engineering. From the molecular to the system level, mechanical stimuli are …

Osteoarthritis, part of life or a curable disease? A bird's‐eye view

M Englund - Journal of Internal Medicine, 2023 - Wiley Online Library
Osteoarthritis (OA) is a chronic joint disease caused by disruption of joint homeostasis by a
variety of systemic and biomechanical factors. The disease is characterized by degradation …

[HTML][HTML] Recommendations for the management of hip and knee osteoarthritis: a systematic review of clinical practice guidelines

AJ Gibbs, B Gray, JA Wallis, NF Taylor, JL Kemp… - Osteoarthritis and …, 2023 - Elsevier
Objectives Guideline adherence for hip and knee osteoarthritis management is often poor,
possibly related to the quality and/or inconsistent recommendations. This systematic review …

[HTML][HTML] Obesity-related knee osteoarthritis—current concepts

R Shumnalieva, G Kotov, S Monov - Life, 2023 - mdpi.com
The knee is the joint most frequently involved in osteoarthritis and represents a significant
contributor to patient morbidity and impaired functional status. Major risk factors include …

Burden of knee osteoarthritis in 204 countries and territories, 1990–2019: results from the Global Burden of Disease Study 2019

G Yang, J Wang, Y Liu, H Lu, L He… - Arthritis Care & …, 2023 - Wiley Online Library
Objective To report the global, regional, and national estimates of knee osteoarthritis (OA)
burden and associated risk factors (high body mass index [BMI]) by age, sex, and …