Atherosclerosis: recent developments
JLM Björkegren, AJ Lusis - Cell, 2022 - cell.com
Atherosclerosis is an inflammatory disease of the large arteries that is the major cause of
cardiovascular disease (CVD) and stroke. Here, we review the current understanding of the …
cardiovascular disease (CVD) and stroke. Here, we review the current understanding of the …
SARS-CoV-2 pathogenesis
MM Lamers, BL Haagmans - Nature reviews microbiology, 2022 - nature.com
The emergence of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has
caused a devastating pandemic. Although most people infected with SARS-CoV-2 develop …
caused a devastating pandemic. Although most people infected with SARS-CoV-2 develop …
The cGAS–STING pathway and cancer
N Samson, A Ablasser - Nature cancer, 2022 - nature.com
The cyclic GMP–AMP synthase (cGAS)–stimulator of interferon genes (STING) pathway has
emerged as a critical innate immune pathway that, following engagement by DNA, promotes …
emerged as a critical innate immune pathway that, following engagement by DNA, promotes …
Drugging the efferocytosis process: concepts and opportunities
P Mehrotra, KS Ravichandran - Nature reviews Drug discovery, 2022 - nature.com
The daily removal of billions of apoptotic cells in the human body via the process of
efferocytosis is essential for homeostasis. To allow for this continuous efferocytosis, rapid …
efferocytosis is essential for homeostasis. To allow for this continuous efferocytosis, rapid …
Macrophage-targeted nanomedicine for the diagnosis and treatment of atherosclerosis
Nanotechnology could improve our understanding of the pathophysiology of atherosclerosis
and contribute to the development of novel diagnostic and therapeutic strategies to further …
and contribute to the development of novel diagnostic and therapeutic strategies to further …
A molecular single-cell lung atlas of lethal COVID-19
Respiratory failure is the leading cause of death in patients with severe SARS-CoV-2
infection,, but the host response at the lung tissue level is poorly understood. Here we …
infection,, but the host response at the lung tissue level is poorly understood. Here we …
Liver ischaemia–reperfusion injury: a new understanding of the role of innate immunity
H Hirao, K Nakamura… - … reviews Gastroenterology & …, 2022 - nature.com
Liver ischaemia–reperfusion injury (LIRI), a local sterile inflammatory response driven by
innate immunity, is one of the primary causes of early organ dysfunction and failure after …
innate immunity, is one of the primary causes of early organ dysfunction and failure after …
Macrophages: the good, the bad, and the gluttony
Macrophages are dynamic cells that play critical roles in the induction and resolution of
sterile inflammation. In this review, we will compile and interpret recent findings on the …
sterile inflammation. In this review, we will compile and interpret recent findings on the …
Systemic lupus erythematosus pathogenesis: interferon and beyond
Autoreactive B cells and interferons are central players in systemic lupus erythematosus
(SLE) pathogenesis. The partial success of drugs targeting these pathways, however …
(SLE) pathogenesis. The partial success of drugs targeting these pathways, however …
Skin wound healing: normal macrophage function and macrophage dysfunction in diabetic wounds
SM Aitcheson, FD Frentiu, SE Hurn, K Edwards… - Molecules, 2021 - mdpi.com
Macrophages play a prominent role in wound healing. In the early stages, they promote
inflammation and remove pathogens, wound debris, and cells that have apoptosed. Later in …
inflammation and remove pathogens, wound debris, and cells that have apoptosed. Later in …